Tuberculosis and Nontuberculous Mycobacterial Infections

One-third of the world'¬"s human population is currently infected with tuberculosis. Tuberculosis remains epidemic, causing close to two million deaths each year. Most of these deaths occur in developing nations; however, developed nations also struggle with tuberculosis, contending with such growing challenges as drug resistance, immigration, immunosuppression, and nontuberculous mycobacterial infection. Nearly 30 years after the publication of the first edition, the Sixth Edition of this comprehensive reference gathers the most current science and tools available in the fight against tuberculosis, enabling readers to fully understand the underlying mechanisms of tuberculosis and correctly diagnose and manage the disease.Tuberculosis and Nontuberculous Mycobacterial Infections is divided into three sections. Section I presents basic concepts of epidemiology, pathophysiology, diagnosis, medical and surgical therapy, drug-resistant tuberculosis, vaccines, and tuberculosis in enclosed populations. Section II covers both classic and more recent clinical manifestations of tuberculosis infection. Separate chapters address every organ system as well as issues unique to pregnancy, infants and children, HIV infection, organ transplantation and immune reconstitution inflammatory syndrome. Section III explores nontuberculous mycobacterial infections, including a detailed discussion of the clinical syndromes produced by these organisms.All the chapters have been written by leading experts whose experience ranges from basic and clinical research to bedside medicine.New to the Sixth EditionThis Sixth Edition features three new chapters: Tuberculosis in History; Tuberculosis and Organ Transplantation; and Mycobacterium bovis and Other Uncommon Members of the Mycobacterium tuberculosis Complex. The latest edition also examines the most recent epidemiologic and public health issues, including airline-associated infection, tuberculosis in the developing world, and the role of the World Health Organization and Departments of Public Health. All the chapters in the book have been thoroughly updated with the latest basic science, clinical manifestations, and diagnostic and therapeutic recommendations.