Tuberculosis and Nontuberculous Mycobacterial Infections

TUBERCULOSIS

AND NONTUBERCULOUS MYCOBACTERIAL INFECTIONS

SEVENTH EDITION

Complete coverage of every aspect of tuberculosis and related mycobacterial infections

“Tuberculosis appears to be as old as humanity itself.” Despite many advancements since the 1882 identification of Mycobacterium tuberculosis as the causative agent of tuberculosis, it remains one of the top 10 causes of death worldwide and threatens the effectiveness of our therapeutic arsenal. In 2015, 1.8 million people died of tuberculosis and almost half a million new cases of multidrug-resistant tuberculosis were diagnosed.

For Tuberculosis and Nontuberculous Mycobacterial Infections, Dr. Schlossberg assembled an international team of experts to write about nearly every facet of the prevention, diagnosis, and treatment of tuberculosis and nontuberculous mycobacterial infections. In addition to presenting the latest clinical data, epidemiological findings, and policy and strategy recommendations of the World Health Organization, four new chapters cover topics of critical importance:

• The role of therapeutic drug monitoring in mycobacterial infections
• The public health issues of refugees and migrants, and their exposure and transmission of tuberculosis resulting from humanitarian crises
• Diabetes mellitus as a significant risk factor for tuberculosis
• The increased risk of tuberculosis reactivation in people taking tumor necrosis factor alpha inhibitors and other biopharmaceuticals

Other chapters provide detailed information on the clinical, public health, and policy aspects of tracking and treating tuberculosis, including:

• The many presentations of tuberculosis, from pulmonary to ocular and cardiovascular to urogenital
• The complications that tuberculosis and antituberculosis therapy cause to the hematologic and endocrine systems
• Tuberculosis during pregnancy and in infants and children
• Treatment of multidrug-resistant tuberculosis and extensively drug-resistant tuberculosis
• Development of new vaccines
• Nontuberculous infections caused by mycobacteria found throughout our environment

The seventh edition of Tuberculosis and Nontuberculous Mycobacterial Infections is an essential resource for anyone working to prevent and treat tuberculosis and associated infections, from infectious disease specialists and pulmonologists to scientists, policymakers, and epidemiologists.

A truly modern book that offers students, practitioners, and all readers the chance for a full immersion into the science of tuberculosis.”

—MARIO RAVIGLIONE, MD, Global TB Programme, World Health Organization

“It’s difficult to improve on an already excellent book but Dr. Schlossberg and colleagues have done it again!”

—BURKE A. CUNHA, MD, MACP, Infectious Disease Division, Winthrop-University Hospital

“This comprehensive book remains the most popular reference among physicians treating tuberculosis.”

—LEONID HEIFETS, MD, National Jewish Hospital (from a previous edition)

“This book meets a demand for timely information…constitutes a ready and useful reference for general internists and primary care physicians.”

—ANNALS OF INTERNAL MEDICINE (from a previous edition)

If you are looking for online access to the latest clinical microbiology content, please visit www.wiley.com/learn/clinmicronow. 

David Schlossberg, MD, FACP, is Medical Director of the Tuberculosis Control Program at the Philadelphia Department of Public Health. He is Professor of Medicine at the Lewis Katz School of Medicine at Temple University and Adjunct Professor of Medicine at the Perelman School of Medicine at the University of Pennsylvania. He is a graduate of Yale University and Tufts Medical School and completed his medical residency at Mount Sinai Hospital, New York, and his infectious disease fellowship at Emory University, Atlanta. Dr. Schlossberg has received numerous teaching awards and has published more than 100 articles, editorials, and book chapters and 28 books on infectious disease.

Contributors

Preface

I. General Considerations

1. Tuberculosis in History: Did It Change the Way We Live?
Thomas M. Daniel

2. Epidemiology and Host Factors
Jay B. Mehta and Asim K. Dutt

3. Perspectives for Developing New Tuberculosis Vaccines Derived from the Pathogenesis of Tuberculosis
Arthur M. Dannenberg, Jr. and Bappaditya Dey

4. Laboratory Diagnosis and Susceptibility Testing for Mycobacterium tuberculosis
Gary W. Procop

5. Diagnosis of Latent Tuberculosis Infection
Alfred A. Lardizabal and Lee B. Reichman

6. Treatment of Latent Tuberculosis Infection
Connie A. Haley

7. Chemotherapy of Tuberculosis
Thomas E. Dobbs and Risa M. Webb

8. The Role of Therapeutic Drug Monitoring in Mycobacterial Infections
Charles Peloquin

9. Therapy of Multidrug-Resistant and Extensively Drug-Resistant Tuberculosis
Barbara J. Seaworth and David E. Griffith

10. Role of Surgery in the Diagnosis and Management of Tuberculosis
Alan D.L. Sihoe

11. Mycobacterium bovis BCG and New Vaccines for the Prevention of Tuberculosis
Timothy Lahey and C. Fordham Von Reyn

12. Tuberculosis—a World Health Organization Perspective
Giovanni Sotgiu, Giorgia Sulis, and Alberto Matteelli

13. Crisis-Affected Populations and Tuberculosis
Dominik Zenner

14. Tuberculosis in Enclosed Populations
Sorana Segal-Maurer

15. Role of the Health Department in Tuberculosis Prevention and Control—Legal and Public Health Considerations
Carla Jeffries, Phil LoBue, Terence Chorba, Beverly Metchock, and Ijaz Kashef

II. Clinical Syndromes

16. Pulmonary Tuberculosis
Sarah M. Lyon and Milton D. Rossman

17. Upper Respiratory Tract Tuberculosis
Surinder K. Jindal, Aditya Jindal, and Ritesh Agarwal

18. Tuberculous Otomastoiditis
Jonathan M. Hand and George A. Pankey

19. Ocular Tuberculosis
Daniel M. Albert and Meisha L. Raven

20. Central Nervous System Tuberculosis
John M. Leonard

21. Tuberculous Lymphadenitis and Parotitis
Juan Carlos Cataño and Jaime Robledo

22. Urogenital Tuberculosis
André A. Figueiredo, Antônio M. Lucon, and Miguel Srougi

23. Musculoskeletal Tuberculosis
Henry M. Blumberg and Michael K. Leonard, Jr.

24. Cardiovascular Tuberculosis
John A. Crocco

25. Gastrointestinal Tuberculosis
Eric H. Choi and Walter J. Coyle

26. Tuberculous Peritonitis
Urvashi Vaid and Gregory C. Kane

27. Tuberculosis of the Liver, Biliary Tract, and Pancreas
G. Shelton McMullan and James H. Lewis

28. Cutaneous Tuberculosis
Michael K. Hill and Charles V. Sanders

29. Miliary Tuberculosis
Surendra K. Sharma and Alladi Mohan

30. Endocrine and Metabolic Aspects of Tuberculosis
Christopher Vinnard and Emily A. Blumberg

31. Hematologic Complications of Tuberculosis
Shyam S. Balepur and David Schlossberg

32. Tuberculosis in Infants and Children
Jeffrey R. Starke and Gabriella S. Lamb

33. Tuberculosis and Pregnancy—Maternal, Fetal, and Neonatal Considerations
Jane M. Gould and Stephen C. Aronoff

34. Tuberculosis Associated with HIV Infection
Kelly E. Dooley and Jeffrey A. Tornheim

35. Diabetes and Tuberculosis
Blanca I. Restrepo

36. Tuberculosis and Transplantation
José M. Aguado, José Tiago Silva, Palash Samanta, and Nina Singh

37. Biologic Agents and Tuberculosis
Claudia C. Dobler

38. Paradoxical Reactions and the Immune Reconstitution Inflammatory Syndrome
L.W. Preston Church, Amit Chopra, and Marc A. Judson

III. Nontuberculous Mycobacteria

39. Nontuberculous Mycobacteria—Overview
Won-Jung Koh

40. Mycobacterium avium Complex Disease
Charles L. Daley

41. Rapidly Growing Mycobacteria
Barbara A. Brown-Elliott and Julie V. Philley

42. Mycobacterium kansasii
James C. Johnston, Leslie Chiang, and Kevin Elwood

43. Mycobacterium marinum
Alexandra Aubry, Faiza Mougari, Florence Reibel, and Emmanuelle Cambau

44. Mycobacterium bovis and Other Uncommon Members of the Mycobacterium tuberculosis Complex
Jaime Esteban and Maria-Carmen Muñoz-Egea

45. Other Slow-Growing Nontuberculous Mycobacteria
Marvin J. Bittner and Laurel C. Preheim

Index

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