The Tumor Microenvironment

This book will explore the many biological and physical aspects of the tumor microenvironment. The book will include chapters on the various cells that influence tumor growth and function as well as the cell-associated and soluble proteins that can promote invasion and metastasis. Several chapters will describe endothelial cells and pericytes that form tumor vasculature. Insights on the role of progenitor and stem cells will be included. The contribution of the supporting stroma will be addressed in addition to cell-cell signaling and cell-matrix interactions. Additional chapters will describe the influence of infiltrating cells of the immune system on tumor growth.

Physiological Parameters
Combination Strategies Targeting Hypoxia Inducible Factor 1 (HIF-1) for Cancer Therapy	p. 3
The Tumor Microenvironment: New Insights into Regulation of Tumor pH by Carbonic Anhydrases	p. 23
Hypoxia, Gene Expression, and Metastasis	p. 43
Molecular Mechanisms Regulating Expression and Function of Cancer-Associated Carbonic Anhydrase IX	p. 59
Glycolytic Pathway as a Target for Tumor Inhibition	p. 91
Malignant Cells
Aberrant DNA Methylation in Cancer Cells	p. 121
DNA Repair and Redox Signaling	p. 133
Cancer Stem Cells and Microenvironment	p. 169
Epithelial-Mesenchymal Transition in Development and Diseases	p. 187
Invasion and Metastasis	p. 213
Dormancy of Disseminated Tumor Cells: Reciprocal Crosstalk with the Microenvironment	p. 229
Vasculature and Stroma
Impact of Endothelial Progenitor Cells on Tumor Angiogenesis and Outcome of Antiangiogenic Therapy: New Perspectives on an Ongoing Controversy	p. 257
Bone Marrow Derived Mesenchymal Stem/Stromal Cells and Tumor Growth	p. 275
Integrin Signaling in Lymphangiogenesis	p. 289
Role of Pericytes in Resistance to Antiangiogenic Therapy	p. 311
Tumour-Promoting Stromal Myofibroblasts in Human Carcinomas	p. 325
Immune-Mediated Cells
Mast Cells and Tumor Microenvironment	p. 353
Macrophages in the Tumor Microenvironment	p. 371
The Prognostic Significance of Tumor-Infiltrating Lymphocytes	p. 385
The Pro-inflammatory Milieu and Its Role in Malignant Epithelial Initiation	p. 409
Natural Killer Cells for Adoptive Immunotherapy	p. 431
Extracellular Matrix
Fibronectin	p. 457
Collagen in Cancer	p. 477
Integrins and Cancer	p. 509
Matrix Metalloproteinases and Cancer Cell Invasion/Metastasis	p. 531
Tetraspanins and Cancer Metastasis	p. 555
Secreted Proteins
Chemokines and Metastasis	p. 601
Transforming Growth Factor-ß in Lung Cancer, Carcinogenesis, and Metastasis	p. 633
Cooperative Interactions Between Integrins and Growth Factor Signaling in Pathological Angiogenesis	p. 673
The Extracellular Matrix and the Growth and Survival of Tumors	p. 695
Secreted Growth Factors as Therapeutic Targets	p. 711
Adrenomedullin	p. 733
Index	p. 749
Table of Contents provided by Ingram. All Rights Reserved.

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The Tumor Microenvironment

Summary

Table of Contents

Supplemental Materials