The Ubiquitin-Proteasome System and Disease,

This final volume in the series focuses on malfunctions of the ubiquitin-proteasome system and their role in human disease.The editors and authors represent unmatched expertise, comprising virtually all the top scientists in the field, including the pioneers of protein degradation research.From the contents: Ubiquitin and cancer Ubiquitin and liver cancer Muscle atrophy Aggresomes and human disease Parkin and neurodegeneration Chronic neurodegenerative diseases Parkinson's disease Ubiquitin and viruses Druggability of the ubiquitin-proteasome systemRequired reading for molecular and cell biologists, as well as physiologists with an interest in the topic.

John Mayer obtained his MS and PhD degrees from the University of Birmingham (UK). He is currently serving as Professor of Biochemistry at the School of Biomedical Sciences at Nottingham University.
For the past 30 years, he has investigated intracellular proteolysis and particularly the ubiquitin/proteasome system. Presently, he is particularly interested in intracellular proteolysis in relation to neurodegenerative illnesses.

Aaron Ciechanover obtained his MD from the Hebrew University in Jerusalem (Israel), and his PhD from the Technion-Israel Institute of Technology in Haifa, where he is presently serving as Professor of Biochemistry. Professor Ciechanover is known for his discovery of the first ubiquitin system mutant cell, demonstrating the role of the ubiquitin-proteasome proteolytic system in protein degradation in vivo. In 2004, he has received the Nobel Prize in Chemistry for his ground-breaking work on the ubiquitin-proteasome system.

Martin Rechsteiner is Professor of Biochemistry at the University of Utah in Salt Lake City (USA). He is interested in the proteasome component of the ubiquitin-proteasome pathway. He has identified several key regulators of proteasome function and is currently working on their structural and functional elucidation.

Preface
List of Contributors.
Ubiquitin Signaling and Cancer Pathogenesis
Introduction
Ubiquitin in Cancer Pathogenesis
Targeting Ubiquitin Networks in Cancers
Conclusions and Future Perspectives
Regulation of the p53 Tumor-suppressor Protein by Ubiquitin and Ubiquitin-like Molecules
Functional Domains of p53
The Family of Ubiquitin-like Molecules
E3 Ligases for p53
Modifi cation of p53 with Ubiquitin
Requirements for Mdm2-mediated Ubiquitination of p53
Regulation of p53 Ubiquitination
De-ubiquitination of p53
SUMO-1/sentrin/smpt3
NEDD8/Rub1
Therapeutic Intervention through the Ubiquitin Pathway
The Ubiquitin–Proteasome System in Epstein-Barr Virus Infection and Oncogenesis
Introduction
Viral Interference with the Ubiquitin–Proteasome System
The EBV Life Cycle
EBV and the Ubiquitin–Proteasome System
EBV-associated Malignancies
Concluding Remarks
HECT Ubiquitin-protein Ligases in Human Disease
Introduction
Defi nition of HECT E3s
Human HECT E3s and their Role in Disease
E6-AP
HECTH9
HECT E3s with WW Domains
Concluding Remarks
Ubiquitin-independent Mechanisms of Substrate Recognition and Degradation by the Proteasome
Introduction
Ubiquitin-independent Proteasome Substrates
Mechanisms of Ubiquitin-independent Degradation
Conclusion
Endoplasmic Reticulum Protein Quality Control and Degradation
Introduction
ER-import, Folding and the Unfolded Protein Response
General Principles and Components of ERQD (Endoplasmic Reticulum Quality Control and Protein Degradation)
Mechanism of ERQD.6.5 “Overfl ow” Degradation Pathways: ER-to-Golgi Transport and Autophagocytosis
The Retrotranslocation Channel
Metazoan ERQD
Interactions between Viruses and the Ubiquitin–Proteasome System
Introduction
Overview of Viruses and the Ubiquitin–Proteasome System
Viruses and E3 Ubiquitin-Protein Ligases
Conclusions
The Ubiquitin–Proteasome System in Parkinson’s Disease
Introduction
Protein Handling in the CNS
The UPS and Protein Mishandling in PD
Parkin
UCH-L1
¿-Synuclein
Dardarin/LRRK2
PINK1
DJ-1
Proteasomal Dysfunction in Sporadic PD
Conclusion
The Molecular Pathway to Neurodegeneration in Parkin-Related Parkinsonism
Introduction
Parkin is an E3 Ubiquitin Ligase
Substrates of Parkin
The Animal Models of AR-JP
Future Directions
Table of Contents provided by Publisher. All Rights Reserved.

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The Ubiquitin-Proteasome System and Disease, Volume 4

Summary

Author Biography

Table of Contents

Supplemental Materials