Werner and Ingbar's the Thyroid
, by Braverman, Lewis E.; Utiger, Robert D., M.D.; Ingbar, Sidney H.; Werner, Sidney C.
- ISBN: 9780397514069 | 0397514069
- Cover: Hardcover
- Copyright: 1/1/1996
| Preface | p. ix |
| Preface to the First Edition | p. xi |
| Contributing Authors | p. xiii |
| The Normal Thyroid | |
| History, Ontogeny, and Anatomy | |
| The Heritage of the Thyroid | p. 3 |
| Normal Development of the Hypothalamic-Pituitary-Thyroid Axis | p. 7 |
| Anatomy | |
| Comparative Anatomy and Physiology | p. 20 |
| Anatomy and Pathology of the Thyrotrophs | p. 43 |
| Thyroid Synthesis and Secretion | |
| Thyroid Hormone Synthesis | |
| Thyroid Iodide Transport: The Na[superscript +]/I[superscript -] Symporter (NIS) | p. 52 |
| Hormone Synthesis: Thyroid Iodine Metabolism | p. 61 |
| Autoregulatory Actions of Iodine | p. 85 |
| Thyroglobulin: Chemistry, Biosynthesis, and Proteolysis | p. 91 |
| Peripheral Hormone Metabolism | |
| Thyroid Hormone Transport Proteins and the Physiology of Hormone Binding | p. 105 |
| Nature and Sources of Circulating Thyroid Hormones | p. 121 |
| Intracellular Pathways of Iodothyronine Metabolism | p. 136 |
| Thyroid Hormone Action | |
| Molecular Actions of Thyroid Hormone | p. 174 |
| Thyroid Hormone Structure-Function Relationships | p. 196 |
| Factors that Control Thyroid Function | |
| Thyrotropin | |
| Chemistry and Biosynthesis of Thyrotropin | p. 202 |
| The Thyrotropin Receptor | p. 219 |
| Biological Actions of Thyrotropin | p. 227 |
| Regulation of Thyrotropin Secretion | p. 234 |
| Intrinsic and Extrinsic Variables Age-Related Changes in Thyroid Function | p. 254 |
| Environmental Influences upon Thyroid Hormone Regulation | p. 257 |
| Effects of Drugs and Other Substances on Thyroid Hormone Synthesis and Metabolism | p. 265 |
| Nonthyroidal Illness | p. 281 |
| Iodine Deficiency | p. 295 |
| Effect of Excess Iodide: Clinical Aspects | p. 316 |
| Laboratory Assessment of Thyroid Function | |
| Radioisotopes and Direct Tests of Thyroid Function | |
| Radiation Physics | p. 333 |
| Biologic Effects of Radioiodines on the Human Thyroid Gland | p. 345 |
| In Vivo Radionuclide Tests and Imaging | p. 355 |
| Serum Thyrotropin and Thyroid Hormone Measurements and Assessment of Thyroid Hormone Transport | p. 376 |
| Miscellaneous Tests | |
| Metabolic, Physiologic, and Clinical Indexes of Thyroid Function | p. 393 |
| Thyroglobulin | p. 402 |
| Thyroid-directed Antibodies | p. 414 |
| Nonisotopic Techniques of Thyroid Imaging | p. 432 |
| Evaluation of Thyroid Nodules by Needle Biopsy | p. 441 |
| Introduction to Thyroid Diseases | |
| Surgical Anatomy | p. 455 |
| Physical Examination of the Thyroid Gland | p. 462 |
| The Epidemiology of Thyroid Diseases | p. 467 |
| Genetic Factors in Thyroid Disease | p. 474 |
| Pathology of Thyroid Diseases | p. 488 |
| Thyroid Diseases: Thyrotoxicosis | |
| Introduction | |
| Introduction to Thyrotoxicosis | p. 515 |
| Causes of Thyrotoxicosis | |
| Graves' Disease | |
| Pathogenesis | p. 518 |
| Ophthalmopathy | p. 531 |
| Localized Myxedema and Thyroid Acropachy | p. 548 |
| Thyrotropin-induced Hyperthyroidism | p. 556 |
| Toxic Adenoma and Toxic Multinodular Goiter | p. 564 |
| Hyperthyroidism Caused by Chorionic Gonadotropin | p. 573 |
| Sporadic Silent Thyroiditis, Postpartum Thyroiditis, and Subacute Thyroiditis | p. 578 |
| Thyrotoxicosis of Extrathyroid Origin | p. 590 |
| Organ System Manifestations of Thyrotoxicosis | |
| The Skin in Thyrotoxicosis | p. 593 |
| The Cardiovascular System in Thyrotoxicosis | p. 596 |
| The Pulmonary System in Thyrotoxicosis | p. 605 |
| The Kidneys and Electrolyte Metabolism in Thyrotoxicosis | p. 617 |
| The Gastrointestinal Tract and Liver in Thyrotoxicosis | p. 622 |
| The Blood in Thyrotoxicosis | p. 627 |
| The Neuromuscular System and Brain in Thyrotoxicosis | p. 631 |
| The Pituitary in Thyrotoxicosis | p. 634 |
| The Adrenal Cortex in Thyrotoxicosis | p. 637 |
| Catecholamines and the Sympathoadrenal System in Thyrotoxicosis | p. 642 |
| The Male and Female Reproductive Systems in Thyrotoxicosis | p. 652 |
| The Skeletal System in Thyrotoxicosis | p. 659 |
| Metabolic Changes in Thyrotoxicosis | p. 667 |
| Behavioral and Psychiatric Aspects of Thyrotoxicosis | p. 673 |
| Thyrotoxic Storm | p. 679 |
| Management of Thyrotoxicosis | |
| Diagnosis of Thyrotoxicosis | p. 685 |
| Treatment of Thyrotoxicosis | p. 691 |
| Thyroid Diseases: Hypothyroidism | |
| Introduction | |
| Introduction to Hypothyroidism | p. 719 |
| Causes of Hypothyroidism | |
| Chronic Autoimmune Thyroiditis | p. 721 |
| Hereditary Metabolic Disorders Causing Hypothyroidism | p. 733 |
| Endemic Cretinism | p. 743 |
| Primary Hypothyroidism Due to Other Causes | p. 755 |
| Central Hypothyroidism | p. 762 |
| Organ System Manifestations of Hypothyroidism | |
| The Skin and Connective Tissue in Hypothyroidism | p. 774 |
| The Cardiovascular System in Hypothyroidism | p. 777 |
| The Pulmonary System in Hypothyroidism | p. 783 |
| The Kidneys and Electrolyte Metabolism in Hypothyroidism | p. 790 |
| The Gastrointestinal Tract and Liver in Hypothyroidism | p. 795 |
| The Blood in Hypothyroidism | p. 800 |
| The Neuromuscular System and Brain in Hypothyroidism | p. 803 |
| The Pituitary in Hypothyroidism | p. 811 |
| The Adrenal Cortex in Hypothyroidism | p. 815 |
| Catecholamines and the Sympathoadrenal System in Hypothyroidism | p. 820 |
| The Male and Female Reproductive Systems in Hypothyroidism | p. 824 |
| The Skeletal System in Hypothyroidism | p. 828 |
| Metabolic Changes in Hypothyroidism | p. 833 |
| Behavioral and Psychiatric Aspects of Hypothyroidism | p. 837 |
| Myxedema Coma | p. 843 |
| Management of Hypothyroidism | |
| Diagnosis of Hypothyroidism | p. 848 |
| Treatment of Hypothyroidism | p. 853 |
| Thyroid Diseases: Nontoxic Diffuse and Multinodular Goiter | |
| Pathogenesis of Nontoxic Diffuse and Nodular Goiter | p. 861 |
| Clinical Manifestations and Treatment of Nontoxic Diffuse and Nodular Goiter | p. 866 |
| Thyroid Diseases: Tumors | |
| Carcinoma of Follicular Epithelium | |
| Pathogenesis | p. 875 |
| Molecular Genetics of Tumors of Thyroid Follicular Cells | p. 886 |
| Surgical Therapy | p. 898 |
| Radioiodine and Other Treatment and Outcomes | p. 904 |
| Medullary Thyroid Carcinoma | p. 930 |
| Miscellaneous Tumors of the Thyroid | p. 944 |
| Clinical Evaluation of Solitary Thyroid Nodules | p. 949 |
| The Thyroid in Infancy and Childhood | |
| Thyroid Physiology in the Perinatal Period and During Childhood | p. 959 |
| Hypothyroidism in Infants and Children Neonatal Screening | p. 973 |
| Congenital Hypothyroidism | p. 977 |
| Acquired Hypothyroidism in Infants, Children, and Adolescents | p. 983 |
| Graves' Disease in the Neonatal Period and Childhood | p. 989 |
| Special Topics in Thyroidology | |
| Subclinical Hypothyroidism | p. 1001 |
| Subclinical Thyrotoxicosis | p. 1007 |
| Thyroid Disease During Pregnancy | p. 1013 |
| Resistance to Thyroid Hormone | p. 1028 |
| Infectious Thyroiditis | p. 1044 |
| Subject Index | p. 1051 |
| Table of Contents provided by Syndetics. All Rights Reserved. |
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