- ISBN: 9781420042818 | 1420042815
- Cover: Hardcover
- Copyright: 7/23/2007
Featuring the work of pioneering investigators, including Nobel Laureate, Dr. Stanley Prusiner, this comprehensive volume begins with a study of the mechanisms of fibril formation and cellular response and discusses emerging diagnostic and translational approaches. It covers-· Possible horizontal transmission· Charge differences of deposits in AL and NALCDD· Novel assays to detect amyloid induced apoptosis· AA and localized amyloidosis· Hereditary gelsolin amyloidosis, and other novel mutations· ALBASE as a platform analysis tool· AL amyloidosis in the elderly· Naturally occurring antibodies as a potential therapy· Clinical trials of melphalan-dexamethasone· Autologous stem cell transplantation
| The effect of membranes and surfaces on the fibrillation of an amyloidogenic light chain : relevance to the etiology of AL amyloidosis | p. 3 |
| Heparan sulfate promotes the refolding and oligomerization of SAA1.1 : a short sequence is implicated in this misfolding process | p. 7 |
| Mouse senile amyloidosis : possible horizontal transmission in the mouse room | p. 10 |
| Charge differences of deposits in AL and NALCDD | p. 13 |
| Role of the C-terminal amino acids in [beta][subscript 2]-microglobulin amyloid formation | p. 16 |
| Serum amyloid A generates high-density lipoprotein from human aortic smooth muscle cells | p. 19 |
| Amyloid light chains localize to lysosomes and cardiac fibroblasts show reduced mitochondrial function | p. 22 |
| Cerebrospinal fluid and plasma of Alzheimer patients promote [beta]-amyloid fibril formation in vitro | p. 25 |
| A novel assay for detection of amyloid induced apoptosis | p. 27 |
| Human amyloidogenic immunoglobulin light chains alter cardiomyocyte signaling and disrupt heparan sulfate proteoglycan (HSPG) expression | p. 30 |
| GAGs associated with fibril extracts mediate fibrillogenesis in AL amyloidosis | p. 33 |
| Decorin in AA amyloidosis | p. 36 |
| Structural evolution of immunoglobulin light chain during amyloid fibril formation : a deep UV resonance Raman spectroscopic study | p. 39 |
| AA amyloidogenesis : basic and translational research | p. 45 |
| Histochemical and immunohistochemical characteristics of amyloid deposits | p. 50 |
| Ultrastructural characteristics of amyloid deposits | p. 53 |
| Odontogenic feline and canine tumor-associated amyloid is formed from ameloblastin | p. 56 |
| Amyloidogenic region of odontogenic ameloblast associated protein (ODAM) | p. 59 |
| What is the best way to assess predisposition to AA amyloid in inflammatory joint disease? | p. 62 |
| Advances in non-invasive imaging of AA amyloid in mice | p. 65 |
| Detection and identification of amyloid deposition associated with human unerupted tooth follicles | p. 68 |
| Vascular AA amyloid formation modeled in cell culture | p. 70 |
| Amyloidosis in ankylosing spondylitis - unexpected findings underscoring the importance of typing of amyloid deposits | p. 73 |
| Lack of correlation between amyloid A protein levels and clinical parameters in aspirated fat tissue of familial Mediterranean fever patients with secondary amyloidosis | p. 75 |
| Chronic, slowly progressing nephropathy due to amyloidosis of CSAA (SAA4) origin | p. 78 |
| Redistribution, clearance and re-induction of amyloid in reactive murine AA amyloidosis | p. 81 |
| N-formyl peptide receptor-like 1 of the neutrophils in the AA-amyloidosis tissues is less stained | p. 84 |
| AL in the clinical setting of AA : the importance of amyloid typing | p. 88 |
| Foie gras is a dietary source of AEF | p. 90 |
| The effect of a variety of anti-inflammatory drugs on murine amyloidogenesis | p. 93 |
| Translocation of systemic amyloidosis by peripheral blood monocytes | p. 96 |
| FK506 inhibits murine AA amyloidosis without modulating serum SAA levels | p. 99 |
| Local tumorous AA-amyloid deposition in a case of hepatic adenomatosis : immunohistochemistry and in situ hybridization employing SAA-mRNA probes | p. 102 |
| SAA[subscript 4]-related AA amyloidosis | p. 105 |
| Measurement of amyloidogenic SAA isotype, SAA1 | p. 108 |
| In vitro and in vivo effects of genistein on TTR stabilization and aggregation | p. 113 |
| Labial salivary gland biopsy for diagnosis of amyloid polyneuropathy Portuguese type | p. 116 |
| Hereditary gelsolin amyloidosis in an Iranian family : the first report from the Middle East | p. 118 |
| A case of compound heterozygosity in a Nigerian male with identification of a new transthyretin variant Phe44Leu and Val122Ile | p. 121 |
| Suppression of hepatic transthyretin synthesis by antisense oligonucleotides | p. 124 |
| Top-down mass spectrometry analysis of amyloidogenic proteins | p. 127 |
| ATTR (Thr59Lys) amyloidosis with involvement of heart, peripheral and autonomic nervous system, gut and salivary glands in an Egyptian man, previously diagnosed as "familial amyloid neuropathy of Portuguese type" | p. 130 |
| Systemic amyloidosis of fibrinogen origin in the wild living stone marten (Martes foina) | p. 133 |
| Familial amyloid nephropathy of fibrinogen A[alpha] (E526V) origin. Report of the first case from Austria | p. 136 |
| Laryngeal amyloidosis in patients with apolipoprotein AI L174S and L178P | p. 139 |
| Hereditary fibrinogen A [alpha]-chain amyloidosis : clinical features and the curative role of liver transplantation | p. 141 |
| Amyloidosis in the transgenic mice of mouse amyloidogenic apolipoprotein A-II (Apoa2[superscript c]) | p. 143 |
| Urinary transthyretin : a possible biochemical marker in the early stage of renal dysfunction | p. 146 |
| Unique phenotype of vitreous amyloidosis in different endemic areas | p. 149 |
| Composition of peripheral nerve amyloid after orthotopic liver transplant for FAP | p. 152 |
| Characterization of fibrillar transthyretin in ex vivo cardiac deposits from cases of senile systemic amyloidosis | p. 154 |
| Comparison of cardiac amyloidosis associated with wild type transthyretin and the isoleucine 122 variant | p. 157 |
| AL amyloidosis in a patient with a T60A TTR mutation | p. 160 |
| Biochemical characterization of leptomeningeal amyloid in a Val30Gly transthyretin patient | p. 163 |
| Apolipoprotein A-I (apo A-I) nature of knee joint meniscus-associated amyloid | p. 166 |
| An autopsy case of familial amyloidotic polyneuropathy ATTR Val30Met 10 years after liver transplantation : changes in the amount of amyloid deposits in the pancreas | p. 169 |
| Amyloid neuropathy in a Japanese domino liver-transplanted recipient | p. 172 |
| The natural history of hereditary apolipoprotein A-I amyloidosis according to a large series of Italian Leu75Pro patients | p. 175 |
| Domino liver transplantation using the explanted grafts from patients with hereditary forms of amyloidosis : the King's College Hospital experience | p. 178 |
| Cardiomyopathy in FAP Val30Met patients with and without liver transplantation | p. 180 |
| Detection of cardiac pre-amyloid deposits of transthyretin by MALDI-TOF | p. 182 |
| Effect of nitric oxide in transthyretin-related amylodiosis | p. 185 |
| Inhibition of intracellular tetramerization induces the proteasomal degradation of amyloidogenic transthyretin variants | p. 188 |
| Structural analyses of fibrinogen A[alpha]-chain amyloid fibrils | p. 191 |
| A transthyretin mutation (V32A) in an Israeli patient with amyloidotic neuropathy localizes to a 3D mutation cluster | p. 193 |
| Amyloid deposition in the tongue of patients with familial amyloidotic polyneuropathy | p. 196 |
| Recent novel and rare mutations in a clinic population of patients with amyloidosis | p. 199 |
| Proliferation of smooth muscle cells in the tunica intima of cerebral vessels in familial amyloidotic polyneuropathy ATTR Y114C | p. 202 |
| Reengineering TTR amyloid inhibition properties of diflunisal | p. 205 |
| Familial amyloidosis associated with a novel mutation (D68G) in the lysozyme gene | p. 208 |
| Effects of liver transplantation on hereditary cerebral amyloid angiopathy associated with ATTR Y114C | p. 211 |
| Effect of tacrolimus and cyclosporine on transthyretin (TTR) metabolism in rats : a long term analysis | p. 214 |
| Can AL amyloidosis be cured? | p. 219 |
| Identification of novel inhibitors of light chain fibrillogenesis | p. 222 |
| Peptide phage display and epitope mapping of a fibril-related conformational epitope recognized by the 11-1F4 monoclonal antibody | p. 225 |
| The translocation t(11;14) is frequently detected in patients with AL amyloidosis | p. 228 |
| ALBase : a platform analysis tool for the study of amyloid light chain sequence data | p. 231 |
| Risk-adapted melphalan with stem cell transplant (SCT) and adjuvant dexamethasone (dex) +/- thalidomide (thai) achieves low treatment-related mortality and high hematologic response rates | p. 234 |
| A supervised analysis of gene-expression profiles of purified clonal plasma cells from patients with systemic light-chain amyloidosis (AL) who have high or low levels of serum free lambda light chains | p. 237 |
| Comparison of immunoglobulin light chains (K1) : amyloidogenic vs. non-amyloidogenic proteins | p. 240 |
| Clinicopathological analysis of thirty-two patients with AL amyloidosis : four-years experience in a single institution | p. 243 |
| Role of light chain deamidation in the pathogenesis of AL amyloidosis | p. 246 |
| The extent and distribution of amyloid in 38 autopsies on patients with primary (AL) amyloidosis | p. 249 |
| Transplantation without growth factor engraftment kinetics following stem cell transplantation for primary systemic amyloidosis | p. 252 |
| Extent of hematologic response is important in determining outcome in transplanted patients with primary systemic amyloidosis. Importance of achieving a complete response | p. 255 |
| A single-center experience using chemotherapy with melphalan-dexamethasone (M-dex) in patients with AL amyloidosis and advanced organ involvement not eligible for high-dose melphalan therapy (HDM) | p. 258 |
| Detection and characterization of AL light chain proteins from fibrils | p. 261 |
| Characterization of post-translational modifications of an amyloidogenic immunoglobulin kappa light chain by mass spectrometry | p. 264 |
| Involvement of lysosomes in renal AL-amyloidogenesis | p. 267 |
| Thermal unfolding of immunoglobulin light chains is linked to aggregation : circular dichroism and light scattering studies | p. 270 |
| Prognostic relevance of serum N-terminal pronatriuretic peptide type B and plasma BNP in patients with AL amyloidosis in dialysis | p. 273 |
| AL amyloidosis in the elderly : a review of 330 patients | p. 275 |
| Therapeutic potential of naturally occurring fibril-reactive human antibodies for AL amyloidosis | p. 278 |
| Prolonged follow-up study of AL patients ineligible for stem cell transplantation treated with oral melphalan and dexamethasone | p. 281 |
| Left ventricular systolic function in patients with cardiac AL amyloidosis | p. 283 |
| In vitro silencing of amyloidogenic [lambda]6 light chain production | p. 286 |
| Amyloid typing in surgical pathology : experience of a single institution | p. 289 |
| Somatic mutations create potential N-glycosylation sites in the immunoglobulin light chain variable regions in primary amyloidosis | p. 292 |
| A trial of antioxidants to improve cardiac function in patient with AL amyloidosis and cardiac involvement | p. 295 |
| High-dose melphalan chemotherapy with autologous stem cell transplantation in 65 patients with AL amyloidosis : organ progression can be delayed in patients reaching complete remission | p. 298 |
| Table of Contents provided by Blackwell. All Rights Reserved. |
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