Neuroprogression and Staging in Bipolar Disorder

After the original proposals of staging for psychotic disorders developed by McGorry and colleagues, a few systems have been put forward specifically for people with bipolar disorder. There is now consistent evidence that, at least for a significant portion of people with this disease, clinical course and outcome are not as benign as initially described. The evidence thus far points to relevant differences between early and late stages of bipolar disorders in the clinical course of illness, neurobiology and systemic pathology. These differences all suggest that staging is a viable addition to clinical care in bipolar disorder.

Neuroprogression and Staging in Bipolar Disorder provides a comprehensive summary of the current state of the evidence regarding the use of staging systems in bipolar disorder. Edited by the leading researchers in the field, the book systematically covers the theoretical basis for staging, comparisons between different proposals, neurobiological underpinnings, the current evidence-base, limitations and future directions, and clinical implications and recommendations for practice. The book provides a solid and in-depth outline and thus to influence research and practice in the field of bipolar disorder.

Flavio Kapczinski, Clinical Hospital of Porto Alegre, Brazil,Eduard Vieta, University of Barcelona, Spain,Pedro V. S. Magalhaes, Clinical Hospital of Porto Alegre, Brazil,Michael Berk, Deakin University, Melbourne, Australia

Flavio Kapczinski is Professor of Psychiatry, Director of Research and Head of the Molecular Psychiatry Laboratory at the Hospital de Clinicas de Porto Alegre, Brazil. He is Consultant for the National Council of Scientific and Technological Development (CNPq). He has wide experience in clinical research, being lead investigator in several clinical trials, some funded by the Stanley Medical Research Institute and Brain & Behavioral Foundation. His work identified biological underpinnings of the decline in cognition and physical health among patients with bipolar disorder. He has published over 302 peer-reviewed papers and has 4700 citations with an H-index of 35. Recently his research has focused on neurotoxicity mechanisms linked to mood episodes and the use of a systemic toxicity index, supporting the notion that bipolar disorder is a systemic illness, approximating psychiatry to other fields of medicine. He currently coordinates the Brazilian National Institute of Translational Medicine.

Eduard Vieta is Professor of Psychiatry, Head of Department and Director of the Bipolar Disorders Program of the Hospital Clinic at the University of Barcelona, Spain. He is Director of the Bipolar Research Program at the Spanish Research Network on Mental Diseases (CIBERSAM) funded by the Spanish Ministry of Science and Innovation. His research focuses on the neurobiology, epidemiology and treatment of bipolar disorder. He received the 2007 Aristotle Award, the 2005 Mogens Schou Award and the 2012 Colvin Prize on Outstanding Achievement in Mood Disorders Research by the Brain and Behaviour Research Foundation. Having made significant contributions to many published bipolar disorder treatment guidelines he has authored over 500 articles, 200 chapters and 27 books. His H index is 58 with over 12000 citations. He is on editorial boards of many international scientific journals. He has served as Invited Professor at Harvard University and Neuroscience Scientific Advisor to the European Presidency.

Pedro V. S. Magalhaes currently serves as Post-Doctoral Research Fellow in translational psychiatry at the National Institute for Translational Medicine in Brazil, before which he was Assistant Professor of Physiology, Biostatistics and Pharmacology at LaSalle University, Canoas from 2011 to 2012. In 2012 he received the Ministry of Education and Culture of Brazil Award for best doctoral thesis of 2011 (Medicine II) and the Samuel Gershon Award for Young Investigator (International Society for Bipolar Disorders). The fundamental nexus of his research career has been an effort for using research methods effectively in the investigation of bipolar disorder. He also holds the post of Junior Editor at RBP Psychiatry. The main lines of research he has developed and continues in recent years include translational medicine and epidemiology, clinical trials and systematic reviews.

Michael Berk is Professor and Alfred Deakin Chair of Psychiatry at Deakin University and Honorary Professorial Research Fellow in the Department of Psychiatry at the Florey Institute for Neuroscience and Mental Health and Orygen Youth Health at Melbourne University. He has published over 450 papers on mood disorders, his greatest contribution being the discovery and implementation of novel therapies. He has published 25 self-initiated randomised controlled trials, pioneering randomised placebo controlled trials of N-acetyl cysteine in depression and bipolar disorder maintenance treatment, establishing an entirely new treatment and implicating a novel mechanism of disease. He was founding editor of the Journal of Depression and Anxiety and has been involved with 12 other journals. He holds grants from the National Institutes of Health (US), Simon Autism Foundation, NHMRC CRE and Stanley Medical Research Institute and is lead investigator on a successful Collaborative Research Centre application.

Foreword, Willem Nolem
1. Clinical staging in bipolar disorder: a historical perspective, Robert M. Post
2. Staging systems in bipolar disorder, Ralph W. Kupka, Manon H. J. Hillegers and Jan Scott
3. Allostatic load and accelerated aging in bipolar disorder, Iria Grande, Luis Guilherme Streb and Flavio Kapczinski
4. Neuroprogression as the biological underpinning of staging in bipolar disorder, Gabriel R. Fries, Pedro V. S. Magalhaes, Flavio Kapczinski and Michael Berk
5. Functioning and illness progression in bipolar disorder, Adriane R. Rosa, Clarissa S. Gama and Eduard Vieta
6. Cognition and illness progression in bipolar disorder, Anabel Martinez-Aran, Caterina del Mar Bonnin, Carla Torrent, Brisa Sole, Imma Torres and Esther Jimenez
7. Social cognition and staging in bipolar disorder, Sergio A. Strejilevich and Diego J. Martino
8. Affective temperaments: potential latent stages of bipolar disorders, Gustavo H. Vazquez and Xenia Gonda
9. Neuroimaging and illness progression, Benicio N. Frey, Luciano Minuzzi, Bartholomeus C.M. Haarman and Roberto B. Sassi
10. Biomarkers in illness progression in bipolar disorder, Aroldo A. Dargel and Marion Leboyer
11. Childhood adversity and illness progression in bipolar disorder, Joana Bucker, Marcia Kauer-Sant'Anna and Lakshmi N. Yatham
12. Vascular and Metabolic Medical Comorbidities and Neuroprogression in Bipolar Disorder, Anusha Baskaran, Benjamin I. Goldstein and Roger McIntyre
13. Substance misuse in staging bipolar affective disorder, Romain Icick and Frank Bellivier
14. Excellent lithium responders, resilience and staging in bipolar disorder, Janusz K. Rybakowski
15. Staging and early intervention in bipolar disorder, Vicent Balanza-Martinez, Maria Lacruz and Rafael Tabares-Seisdedos
16. Pharmacological treatment of late-stage bipolar disorder, Aline Andre Rodrigues and Mauricio Kunz
17. Illness progression and psychosocial interventions in bipolar disorder, Maria Reinares and Francesc Colom
18. Staging systems in bipolar disorder: current findings, future directions and implications for clinical practice, Flavio Kapczinski, Eduard Vieta, Pedro V. S. Magalhaes and Michael Berk