Neuroprogression in Psychiatry

Recent studies regarding the neuropathology of specific neurological disorders suggest that both neurodevelopmental and neurodegenerative processes may play a role. However, in contrast to the neurodegeneration seen in neurological disorders such as Parkinson's and Alzheimer's disease, the term "neuroprogression" has been used to describe the neurodevelopmental aspect of pathological brain re-wiring that takes place in the context of severe psychiatric disorders, such as schizophrenia or bipolar disorder. Within psychiatry, patients with severe psychopathology, such as those depressed patients who eventually commit suicide, have been shown to present with increased inflammatory markers in the brain. A similar increase in inflammatory markers is also found in patients with bipolar disorders and schizophrenia. Thus, oxidative stress, inflammation, and changes in growth factors are thought to be the pathways of neuroprogression.

Neuroprogression in Psychiatry provides a comprehensive summary of the current developments in the emerging field of neuroprogression. With contributions by leading researchers in the field, this book examines the role of neuroprogression across a wide range of specific psychiatric disorders, with chapters included on major depressive disorder, anxiety disorder, post-traumatic stress disorder, substance abuse, schizophrenia, and bipolar disorder.

Flavio Kapczinski, Professor, Department of Psychiatry and Behavioural Neurosciences, Director, Graduate Program in Neuroscience, McMaster University, Hamilton, ON, Canada,Michael Berk, Alfred Deakin Chair of Psychiatry, School of Medicine, Deakin University, Geelong, VIC, Australia; NHMRC Senior Principal Research Fellow, Department of Psychiatry, University of Melbourne, Parkville, VIC, Australia; Honorary Professorial Research Fellow, Florey Institute for Neuroscience and Mental Health and Orygen Youth Health, University of Melbourne, Parkville, VIC, Australia,Pedro Vieira da Silva Magalhaes, Adjunct Professor, Department of Psychiatry and Legal Medicine, Professor, Postgraduate Program in Psychiatry and Behavioral Sciences, Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil

Flavio Kapczinski is a Professor in the Department of Psychiatry and Behavioural Neurosciences, and the Director of the Graduate Program in Neuroscience at McMaster University, Hamilton, ON, Canada.

Michael Berk is the Alfred Deakin Chair of Psychiatry in the School of Medicine, Deakin University, Geelong, VIC, Australia. He is also the NHMRC Senior Principal Research Fellow in the Department of Psychiatry at the University of Melbourne, Parkville, VIC, Australia, as well as an Honorary Professorial Research Fellow at the Florey Institute for Neuroscience and Mental Health and Orygen Youth Health, University of Melbourne, Parkville, VIC, Australia.

Pedro Vieira da Silva Magalhaes is an Adjunct Professor in the Department of Psychiatry and Legal Medicine, and a Professor for the Postgraduate Program in Psychiatry and Behavioral Sciences, at the Federal University of Rio Grande do Sul (UFRGS), Porto Alegre, RS, Brazil.

1. A short introductory note on neuroprogression and staging in psychiatry, Luis Guilherme Streb, Michael Berk, and Flavio Kapczinski
2. Allostasis and neuroprogression in major psychiatric disorders, Iria Grande, Flavio Kapczinski, Sebastian Caminoa, Gustavo Vazquez, and Eduard Vieta
3. Neuroprogression and accelerated aging in severe psychiatric disorders, Elisa Brietzke, Ana S. Yamagata, Pawan K. Maurya, and Lucas B. Rizzo
4. Mitochondrial function and inflammation pathways in the neuroprogression of mental disorders, Ana C. Andreazza, Rajas P. Kale, Angela Duong, Fabio Molina, and Susannah J.Tye
5. The role of immuno-inflammatory abnormalities in neuroprogression, Elisa Brietzke, Ana S. Yamagata, Raphael Cerqueira, Lucas B. Rizzo, Roger S. McIntyre, and Rodrigo B. Mansur
6. Depression and neuroprogression: Sirtuins and mitochondria as crucial hubs, George Anderson and Michael Maes
7. Neuroprogression in post-traumatic stress disorder, Ryan M. Cassidy, Ives Cavalcante Passos, and Marcia Kauer-Sant'Anna
8. Neuroprogression in anxiety disorders, Giampaolo Perna, Elisa Mingotto, Alessandra Alciati, and Daniela Caldirola
9. Functioning and illness progression in severe mental illness, Adriane R. Rosa and Flavia Lima
10. Neuropsychological functioning and neuroimaging in bipolar disorder: Evidence of neuroprogression, Emre Bora
11. Neuroprogression in children and adolescents with bipolar disorder, Francisco Romo-Nava, Jenni Farrow, Luis Rodrigo Patino, Fabiano Nery, Caleb M. Adler, and Melissa P. DelBello
12. Substance abuse and neuroprogression, Anne Orgler Sordi, Silvia Bassani Schuch-Goi, and Lisia von Diemen
13. Lifestyle and neuroprogression: Diet, sleep, and exercise, Adrian L. Lopresti and Peter D. Drummond
14. The pernicious procession of somatoprogression, Jonathan M. Gregory, Benjamin I. Goldstein, and Roger S. McIntyre