Chronic Liver Failure

Chronic liver failure is a frequent condition in clinical practice that encompasses all manifestations of patients with end-stage liver diseases. Chronic liver failure is a multiorgan syndrome that affects the liver, kidneys, brain, heart, lungs, adrenal glands, and vascular, coagulation, and immune systems.Chronic Liver Failure: Mechanisms and Management covers for the first time all aspects of chronic liver failure in a single book, from pathogenesis to current management. Each chapter is written by a worldwide known expert in their area and all provide the latest state-of-the-art knowledge. This volume is specifically designed to provide answers to clinical questions to all doctors dealing with patients with liver diseases, not only clinical gastroenterologists and hepatologists, but also to internists, nephrologists, intensive care physicians, and transplant surgeons.

Preface	p. v
Acknowledgements	p. ix
Contributors	p. xv
The Organ
Cells in the Liver-Functions in Health and Disease	p. 3
Liver Physiology	p. 33
Assessment of Liver Function in Clinical Practice	p. 47
Physiology of the Splanchnic and Hepatic Circulations	p. 77
Fibrosis as a Major Mechanism of Chronic Liver Disease	p. 91
Stem Cells and Chronic Liver Failure: Potential New Therapeutics	p. 109
The Role of Inflammatory Mediators in Liver Failure	p. 131
Genomics of the Liver in Health and Disease	p. 155
Effects of Liver Failure on Organ Systems
Hepatic Encephalopathy and Alterations of Cerebral Function	p. 171
Bacterial Translocation and Alterations of the Digestive System	p. 189
SIRS, Bacterial Infections, and Alterations of the Immune System	p. 219
Regulation of the Extracellular Fluid Volume and Renal Function	p. 239
The Heart in Chronic Liver Failure	p. 269
Haemostasis Abnormalities in Chronic Liver Failure	p. 289
The Systemic and Splanchnic Circulations	p. 305
Hepatic Microcirculation	p. 323
Angiogenesis and Vascular Growth in Liver Diseases	p. 343
Pulmonary Alterations in Chronic Liver Failure	p. 361
Adrenal Function in Chronic Liver Failure	p. 377
Management of Chronic Liver Failure
Antibiotic Prophylaxis and Management of Bacterial Infections	p. 395
Management of Ascites and Hyponatremia	p. 411
Management of Renal Failure	p. 429
Correction of Abnormalities of Haemostasis in Chronic Liver Disease	p. 453
The Treatment and Prevention of Variceal Bleeding	p. 477
Extracorporeal Artificial Liver Support Systems	p. 501
Issues in Transplantation of Patients with Chronic Liver Failure	p. 521
Chronic Liver Disease in the Intensive Care	p. 541
Subject Index	p. 561
Table of Contents provided by Ingram. All Rights Reserved.

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Chronic Liver Failure

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