Can precision medicine be personal; Can personalized medicine be precise?

Y. Michael Barilan, Full Professor, School of Medicine, Tel Aviv University,Margherita Brusa, Research fellow, Medical Ethics and Law Initiative, Faculty of Medicine, Tel Aviv University, Israel,Aaron Ciechanover, University Professor, Technion-Israel Institute of Technology, Haifa

Yechiel Michael Barilan was born and educated in Israel. He is an expert in Internal Medicine and js most recently a senior physician in the Covid-19 Dept. and Emergency Dept. Tel Aviv Medical Centre. He is a full professor in the Tel Aviv University School of Medicine, specializing in ethics and
social history of medicine. He is also a member of national and international ethics committees and is an author of over a hundred peer reviewed academic publications.


Margherita Brusa earned a PhD in bioethics from the University Complutense of Madrid, and a second PhD in paediatric healthcare planning from the University of Padua. She has served in ethics committees in Spain, USA, and Italy, and led the creation of the first ethics committee in the Palestinian
Authority. The focus of her research is bioethics and children.


Aaron Ciechanover is an Israeli physician and scientist working currently at the Faculty of Medicine of the Technion-Israel Institute of Technology in Haifa, Israel. He received his MD (1972) from the Hebrew University of Jerusalem and PhD (1982) from the Technion, where along with Professor Avram
Hershko and in collaboration with Professor Irwin Rose (Philadelphia, USA) he discovered the Ubiquitin Proteolytic System, a discovery which awarded them numerous prizes, including the Nobel Prize in Chemistry (2004). He is a member of many learned bodies, including the National Academies of
Sciences and Medicine of the USA (Foreign Associate), and the Pontifical Academy of Sciences at the Vatican.

1. Chapter 1: Precision and Persons in Medicine: An Introduction, Yechiel Michael Barilan and Margherita Brusa
2. The historical background of Personalized Medicine, Diego Gracia Guillen
3,. What 21st Century Medicine Should Be-History, Vision, Implementation and Opportunities, Leroy Hood, Nathan D. Price, and Simon J. Evans
4. The Problematic Side of Precision Medicine: A Short Voyage through Some Questions, Giovanni Boniolo
5. The precision paradox - How personalized medicine increases uncertainty, Henrik Vogt
6. Genomics and Precision Medicine: Through a Different Prism, Farhat Moazam
7. Personalization, Individuation and the Ethos of Precision Medicine, Yechiel Michael Barilan
8. Personalized Medicine and Genetic Newborn Screening, Margherita Brusa and Donna Dickenson
9. The Revolution of Personalized Medicine is Already Upon Us in Rare Diseases, Christopher P. Austin
10. Personalized Medicine and Disorders of Consciousness: An Alternate Convergence of Knowledge towards a New Clinical Nosology, Joseph J. Fins
11. Gender and Personalized Medicine: Methodological and Ethical Pitfalls, Marianne J. Legato
12. Potential Challenges to Doctor-Patient Trust Posed by Personalized Medicine, Shlomo Cohen
13. When does precision matter? Personalised medicine from the perspective of public health, James Wilson
14. CRISPR - A Challenge for National and International Regulation, Dianne Nicol
15. The Advent of Automated Medicine? The values and meanings of precision, Barbara Prainsack
16. Thoughtful Genomics, Jenny Reardon
17. Islamic Sunni perspectives on the ethics of precision medicine, Mehrunisha Suleman
18. Genetics, genetic profiles and Jewish law, Yehoshua Weisinger and Yechiel Michael Barilan
19. Pharmaceutical Contributions to Personalized Medicine, Roger Perlmutter