Therapeutic Immunology

Therapeutic Immunology is a comprehensive review of the clinical application of the drugs, biologic agents, and procedures used to treat immunologic diseases. It is the only reference that provides current information on antibodies, cytokines, gene and cell therapies, vaccines, and other therapeutic approaches in the managament of immune system disorders. This book will show how immunology has come of age as a clinical discipline and is now able to provide treatment strategies for many previously incurable diseases.

K. Frank Austen. Astra Zeneca Professor of Respiratory and Inflammatory Diseases Department of Medicine, Emertius Brigham and Women's Hospital Department of Medicine; Division of Rheumatology, Immunology and Allergies.

Contributors

ix

Preface

xv

PART I: INTRODUCTION

1

(28)

Adaptive Immunity

3

(15)

Emil R. Unanue

Innate Immunity and Instruction of the Adaptive Immune Response

18

(11)

Douglas T. Fearon

PART II: DRUGS

29

(148)

Antimetabolites and Radiomimetics

Cyclophosphamide

31

(20)

Alfred D. Steinberg

The Purine Antagonists: Azathioprine and Mycophenolate Mofetil

51

(14)

Nina E. Tolkoff-Rubin

Robert H. Rubin

Methotrexate

65

(16)

Michael E. Weinblatt

Immunosupression and Immunophilin Binding Agents: Current Research and Clinical Application

81

(22)

Shairaz Baksh

Jeff Friedman

Steven J. Burakoff

Barbara E. Bierer

Corticosteroids

Glucocorticoid Action

103

(14)

Jeffrey N. Miner

Myles Brown

Anti-Inflammatory Agents

Cyclooxygenase Inhibitors

117

(15)

William L. Smith

David L. DeWitt

Antileukotrienes (Leukotriene Modifiers) in the Treatment of Asthma

132

(8)

Jeffrey M. Drazen

Phosphodiesterase Inhibitors

140

(10)

Nicky Cooper

Mamidipudi Thirumala Krishna

Robert Gristwood

Stephen Holgate

Tryptase Inhibitors

150

(9)

Andrew F. Walls

5-Aminosalicylic Acid (Mesalamine) and Sulfasalazine

159

(9)

Richard P. MacDermott

Antihistamines (H1-Receptor Antagonists)

168

(9)

F. Estelle

R. Simons

PART III: BIOLOGIC AGENTS

177

(280)

Cytokines

Hematopoietic Growth Factors

179

(22)

Colin A. Sieff

Cytokines Regulating Immune Inflammation: Interleukin-4, Interleukin-10, and Interleukin-12

201

(19)

Richard N. Mitchell

Abul K. Abbas

The Interferons: Basic Biology and Therapeutic Potential

220

(20)

Vijay Shankaran

Robert D. Schreiber

Interleukin-21 Immunostimulation

240

(11)

Kendall A. Smith

A Soluble TNF Receptor-Fc Fusion Protein (Etanercept) in the Treatment of Inflammatory Diseases

251

(13)

Michael B. Widmer

Leslie Garrison

Kendall M. Mohler

Macromolecules

Intravenous Immunoglobulin Therapy

264

(23)

Francisco A. Bonilla

Raif S. Geha

Therapeutic Inhibition of Complement Activation with Emphasis on Drugs in Clinical Trials

287

(15)

Lloyd B. Klickstein

Francis D. Moore, Jr.

John P. Atkinson

Treatment of Angioedema Resulting from C1-Inhibitor Deficiency

302

(11)

A. Thomas Waytes

Fred S. Rosen

Antibody-Based Therapy

Inhibitors of Tumor Necrosis Factor

313

(14)

Arthur F. Kavanaugh

Peter E. Lipsky

Targeting the IL-2 Receptor with Antibodies or Chimeric Toxins

327

(5)

Terry B. Strom

Monoclonal Antibodies to CD3

332

(10)

Lucienne Chatenoud

Anti-IgE: Immunotherapy for Allergic Diseases

342

(10)

Donald MacGlashan, Jr.

Immunotherapy of Allergic Disease

Specific and Nonspecific Immunotherapy for Asthma and Allergic Diseases

352

(19)

M. Larche

A.B. Kay

Treatment of Allergy to Insect Stings

371

(12)

Martin D. Valentine

Chimeric Protein

The CD28 T-Cell Costimulatory Pathway: Pharmacologic Inhibition and Augmentation

383

(18)

Carl H. June

Jeffrey A. Ledbetter

Vaccines and Peptide Therapy

Bacterial Vaccines

401

(12)

Hilde-Kari Guttormsen

Dennis L. Kasper

Viral Vaccines

413

(17)

Ronald W. Ellis

DNA Vaccines

430

(11)

Harriet L. Robinson

Blockade of the CD40L/CD40 Pathway

441

(16)

Leonard Chess

PART IV: MANEUVERS

457

(180)

Transplantation

Renal Transplantation

459

(10)

Manikkam Suthanthiran

Terry B. Strom

Pancreas Transplantation

469

(5)

Michael E. Shapiro

Cardiac Transplantation

474

(8)

Abdallah G. Kfoury

David O. Taylor

Dale G. Renlund

Lung Transplantation

482

(14)

Steven J. Mentzer

Scott J. Swanson

Hemopoietic Stem Cell Transplantation

496

(22)

Voravit Ratanatharathorn

James L.M. Ferrara

Cell Transplantation

518

(10)

Luca Inverardi

Alberto Pugliese

Camillo Ricordi

Liver Transplantation

528

(7)

Roberto Gedaly

James J. Pomposelli

Roger L. Jenkins

Xenotransplantation

535

(15)

Tomasz Sablinski

David K.C. Cooper

David H. Sachs

Cellular Therapy

550

(24)

Philip D. Greenberg

Stanley R. Riddell

Genetically Engineered Cancer Vaccines

574

(6)

Glenn Dranoff

Gene Therapy

Gene Therapy for Inherited Immunodeficiencies

580

(17)

Fabio Candotti

R. Michael Blaese

Additional Interventions

Plasmapheresis and Immunoadsorption

597

(15)

Sian Griffin

C. Martin Lockwood

Charles D. Pusey

Drug Therapy for HIV Infection

612

(25)

John P. Doweiko

Jerome E. Groopman

Index

637

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Therapeutic Immunology

Summary

Author Biography

Table of Contents

Supplemental Materials