The Epilepsy Aphasia Spectrum From Landau-Kleffner Syndrome to Rolandic Epilepsy

Thierry Deonna, Emeritus Professor of Neurology, the Child Neurology Unit, University of Lausanne Children's Hospital,the University of Lausanne, Switzerland.

Eliane Roulet-Perez, Professor of Paediatric Neurology at the Faculty of Biology and Medicine, University of Lausanne, Switzerland. Head of the Paediatric Neurology and Neurorehabilitation Unit, Centre Hospitalier Universitaire Vaudois, Lausanne, Switzerland.

Forewords ix

Preface xi

Acknowledgements xiii

1. Introduction 1

2. History of the Landau–kleffner Syndrome 4

3. Classification Issues 18

4. Speech Perception and Brain Organization of Language: Relevant Features for Landau–kleffner Syndrome and The Epilepsy-aphasia Spectrum 26

5. The Different Clinical Facets of Landau–kleffner Syndrome 34

6. Developmental Aspects of Landau–kleffner Syndrome and The Epilepsy-aphasia Spectrum and The Overlap with Developmental Language Disorders and Autism Spectrum Disorder 60

7. Evolution of Landau–kleffner Syndrome: Short-,mid- and long-term Outcomes 70

8. From Rolandic Epilepsy to Landau–kleffner Syndrome 78

9. Laboratory Investigations in Landau–kleffner Syndrome and The Epilepsy-aphasia Spectrum 95

10. Physiopathology of Speech, Language and Other Prolonged Epileptic Dysfunction in Landau–kleffner Syndrome, Epilepsy with Continuous Spike Waves During Sleep and Related Syndromes 106

11. Functional Neuroimaging Investigations in Idiopathic Focal Epilepsies of Childhood with Cognitive and Behavioural Impairment 119
Xavier de Tiège, Serge Goldman, and Patrick van Bogaert

12. Drug Management of Cognitive Impairments in Landau–kleffner Syndrome and Other Epilepsy Aphasia Spectrum Syndromes 127

13. Speech and Language, Educational and Psychological Remediation 137

14. Personal Testimonies and Unpublished Cases 156

15. Summary and Conclusions 167

References 170

Index 187

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