5-ht2c Receptors in the Pathophysiology of

The purpose of this book is to summarize the large work that has explored the pathophysiological role of the 5-HT2C receptor. It will fill a gap in literature since no similar editorial work has recently been published. In addition, the topic is extremely important and of general interest among the scientific community with relevance not only to specialists but also to general practitioners and students. This book will be a very important contribution to the debate on new pharmacological approaches for several psychopathological states. The physiology, pharmacology and anatomical distribution of the 5-HT2C receptors in the CNS will be described first. After, their potential involvement in the pathophysiology of depression, schizophrenia, Parkinson's disease and drug abuse and other disorders such as epilepsy, obesity, sexual dysfunctions will be also discussed.

The Making of the 5-HT_2C Receptor	p. 1
Serotonin 5-HT_2C Receptors: Chemical Neuronatomy in the Mammalian Brain	p. 17
The Medicinal Chemistry of 5-HT_2C Receptor Ligands	p. 29
Insights into 5-HT_2C Receptor Function Gained from Transgenic Mouse Models	p. 51
Serotonin 5-HT_2C Receptor Signal Transduction	p. 75
Homology Modeling of 5-HT_2C Receptors	p. 97
5-HT_2C Receptor Dimerization	p. 129
RNA Editing of 5-HT_2C Receptor and Neuropsychiatric Diseases	p. 157
Serotonergic Control of Adult Neurogenesis: Focus on 5-HT_2C Receptors	p. 169
The Constitutive Activity of 5-HT_2C Receptors as an Additional Modality of Interaction of the Serotonergic System	p. 187
The 5-HT_2C Receptor Subtype Controls Central Dopaminergic Systems: Evidence from Electrophysiological and Neurochemical Studies	p. 215
The Role of 5-HT_2C Receptors in the Pathophysiology and Treatment of Depression	p. 249
5-HT_2C Receptors and Suicidal Behavior	p. 261
The 5-HT_2C Receptor as a Target for Schizophrenia	p. 275
Serotonin and Reward-Related Behavior: Focus on 5-HT_2C Receptors	p. 293
Tat-3L4F: A Novel Peptide for Treating Drug Addiction by Disrupting Interaction Between PTEN and 5-HT_2C Receptor	p. 325
The Role of Serotonin in Eating Behavior: Focus on 5-HT_2C Receptors	p. 339
Physiological and Pathophysiological Aspects of 5-HT_2C Receptors in Basal Ganglia	p. 351
Modeling Tardive Dyskinesia: Predictive 5-HT_2C Receptor Antagonist Treatment	p. 383
The Role of 5-HT_2A/2C Receptors in Sleep and Waking	p. 393
Role of Alternative Splicing of the 5-HT_2C Receptor in the Prader-Willi Syndrome	p. 413
The Role of 5-HT_2C Receptor in Epilepsy	p. 429
The Role of Serotonin on Attentional Processes and Executive Functioning: Focus on 5-HT_2C Receptors	p. 445
5-HT_2C Receptors in Learning	p. 461
The Role of 5-HT_2C Polymorphisms in Behavioral and Psychological Symptoms of Alzheimer Disease	p. 509
Ocular Hypotension: Involvement of Serotonergic 5-HT₂ Receptors	p. 523
Index	p. 545
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5-ht2c Receptors in the Pathophysiology of Cns Disease

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