Evidence-Based Hematology

This unique new book uses a series of focussed questions, comprehensive literature evaluations and structured grades of recommendation to provide evidence for the treatment of hematological disorders, both malignant and benign. With contributions from leading international experts who have a real understanding of evidence-based medicine the book provides comprehensive reviews accompanied by clinical commentaries and recommendations on the best treatment regimes to adopt for individual patients. The book is split into two sections: the first examines the methodology underlying evidence based practice, and the second concentrates on the clinical practice of hematology, providing current "best evidence" to guide practice in a series of well-defined clinical situations. This clinical reference is an invaluable source of evidence-based information distilled into guidance for clinical practice which will be welcomed by practitioners, trainees and associated health professionals.

Dr Mark Crowther is Associate Professor of Medicine and Program Director of the Adult Hematology Residency Training Program at McMaster University. He is a member of the Canadian Critical Care Trials Group.

Dr. Jeffrey Ginsberg is a leading expert in the diagnosis, prevention and management of venous thromboembolism and has led many of the "practice changing" studies published in this area in the last 20 years. He is the recipient of numerous awards and distinctions, most recently an endowed chair at McMaster University allowing him to pursue further research in venous and arterial thrombosis.

Dr. Holger Schünemann is a leading expert in evidence based practice with a particular interest in the development and widespread dissemination of validated evidence scoring criteria. Dr. Schünemann has played an important role in the evolution of evidence based guidelines currently written by organizations such as the American College of Chest Physicians and the American Thoracic Society.

Dr. Ralph Meyer has recently joined the National Cancer Institute of Canada after a distinguished career at McMaster University. Dr. Meyer is responsible for administering the Clinical Trial Program at the NCIC. The NCIC has led or participated in many national and international studies which guide current best treatment practices for disorders such as Hodgkin's disease, multiple myeloma and other hematologic malignancies.

Dr. Richard Lottenberg is a professor of medicine and past Division Chair of the division of Hematology and Oncology. He is currently the Training Program Director at the University of Florida and is widely regarded as an expert in the evidence based management of sickle cell anemia.

About the Contributors
Preface
A Guide to the Evidence
Rating the quality of evidence and making recommendations
An overview of systematic reviews
Interpreting results of clinical research
Finding the evidence
Applying EBM in clinical practice
Using evidence to guide the diagnosis of disease

Diagnosis of Deep Vein Thrombosis
Diagnosis of Pulmonary Embolism
Initial Therapy of Deep Vein Thrombosis and Pulmonary Embolism
Long-term Anticoagulation in Venous Thromboembolism
Thrombolytic Therapy for Deep Vein Thrombosis and Pulmonary Embolism
Inferior Vena Cava Interruption
Management of Venous Thromboembolism in Pregnancy
Pediatric Thrombosis
Bridging Anticoagulation in Patients who Require
Evidence-based approach to the diagnosis and management of thrombotic thrombocytopenic purpura
Diagnosis and Management of Disseminated Intravascular Coagulation
Diagnosis and Management of Hereditary Bleeding Disorders
Diagnosis and Management of Acquired Bleeding Disorders
Diagnosis and Management of Heparin-Induced Thrombocytopenia
Management of Antiphospholipid Antibody Syndrome

Clinical Questions in iron overload
Aplastic Anemia
Acquired Anemias
Immune thrombocytopenic purpura
Neutropenia
Hypereosinophilia
Porphyrias
Membrane and Enzyme Abnormalities of the Erythrocyte
Sickle cell disease
Evidence-based treatment of thalassemia major

Acute Lymphoblastic Leukemia in Adults
Acute Myeloblastic Leukemia in Adults
Acute Myeloid Leukemia in Adults
Current Areas of Controversy in the Treatment of Patients
Chronic Lymphocytic Leukemia
Chronic Myelocytic Leukemia
Burkitt's Lymphoma
Primary Central Nervous System Lymphoma
Diffuse Large B-cell Lymphoma
Follicular Lymphoma
Lymphoblastic Lymphoma
Mantle Cell Lymphoma
Peripheral T-cell Lymphoma
Classical Hodgkin Lymphoma
Nodular Lymphocyte Predominant Hodgkin Lymphoma
Essential Thrombocythemia
Management of Patients with Polycythemia Vera
Multiple Myeloma
Waldenstroms Macroglobulinemia
Use of Hematopoietic Growth Factors for Hematologic Malignancies
Index
Table of Contents provided by Publisher. All Rights Reserved.

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Evidence-Based Hematology

Summary

Author Biography

Table of Contents

Supplemental Materials