Abdominal Aortic Aneurysm Genetics,

An increase in incidence of abdominal aortic aneurysm is predicted as an extension of the advancing age of our population. Novel strategies for treatment and prevention need to be considered. Interdisciplinary approaches to this disease will aid in prevention and treatment. This volume will integrate new insights into the etiology and pathology of aneurismal disease, including physiologic and genetic causes.Several educational objectives have been met in this volume. The contributors assess the benefits of risk of rupture assessment at different ages and thresholds of abdominal aortic aneurysm in the context of epidemiologic studies, examine the use of animal models in the study of abdominal aortic aneurysm and its underlying pathobiology, and integrate data on susceptibility and genetic causes of abdominal aortic aneurysms.The increase in abdominal aortic aneurysms (AAA) is viewed from the perspective of epidemiology, and initiatives to prevent death from rupture are discussed. Animal models and their relevance to pathophysiology and prevention are also presented, and the interventional pharmacology is also considered from the perspective of enzymology.In addition, chapters covering the biological aspects of the endovascular devices used to repair abdominal aortic aneurysm and the molecular biology and immunology in abdominal aortic aneurysm are included.NOTE: Annals volumes are available for sale as individual books or as a journal. For information on institutional journal subscriptions, please visit www.blackwellpublishing.com/nyas.ACADEMY MEMBERS: Please contact the New York Academy of Sciences directly to place your order (www.nyas.org). Members of the New York Academy of Science receive full-text access to the Annals online and discounts on print volumes. Please visit www.nyas.org/membership/main.asp for more information about becoming a member.

M. David Tilson, Columbia University, USA

Helena Kuivaniemi, Wayne State University School of Medicine, USA

Gilbert R. Upchurch, University of Michigan Cardiovascular Center, USA

Introduction
Keynote Remarks: Challenges and Opportunities in Abdominal Aortic Aneurysms Research
Epidemiology and Initiatives to Prevent Death from Rupture
Epidemiology of Aortic Aneurysm Repair in the United States from 1993 to 2003
A Biomechanics-Based Rupture Potential Index for Abdominal Aortic Aneurysm Risk Assessment: Demonstrative Application
Long-term Relationship of Wall Stress to the Natural History of AAAs (Finite Element Analysis and Other Methods)
A Summary of the Contributions of the VA Cooperative Studies on Abdominal Aortic Aneurysms
Pharmacological Approaches to Prevent AAA Enlargement and Rupture
Should Usual Criteria for Intervention in Abdominal Aortic Aneurysms be "Downsized" Considering Reported Risk-Reduction With Endovascular Repair?
Animal Models: Pathophysiology and Biomechanical Aspects
Pathophysiology of Abdominal Aortic Aneurysms: Insights from the Elastase-Induced Model in Mice with Different Genetic Backgrounds
Regression of Abdominal Aortic Aneurysm by Inhibition of c-Jun N-Terminal Kinase in Mice
Role of the Renin-Angiotensin System in the Development of Abdominal Aortic Aneurysms in Animals and Humans
AAA Disease: Mechanism, Stratification and Treatment
Refinements in Mathematical Models to Predict Aneurysm Growth and Rupture
Enzymology - Another Approach to Interventional Pharmacology
AAA - A complex Multifactorial Disease: Interactions of Polymorphisms of Inflammatory Genes, Features of Autoimmunity, and Current Status of MMPs
The Intraluminal Thrombus as a Source of Proteolytic Activity
Activators of Plasminogen and the Progression of Small Abdominal Aortic Aneurysms
Is There a Role for Macrophage 5-Lipoxygenase Pathway in Aortic Aneurysm Development in Apolipoprotein E Deficient Mice?
Do Cathepsins Play a Role in AAA Pathogenesis?
MMP-2: The Forgotten Enzyme in Aneurysm Pathogenesis
Biological Aspects of Endovascular Devices to Repair AAA
Current Status of Endovascular Repair of Infrarenal Abdominal Aortic Aneurysms in the Context of 50 Years of Conventional Repair
Animal Models of Endovascular AAA Repair
Aortic Aneurysm, Thoracoabdominal Aneurysm, Juxtarenal Aneurysm, Fenestrated Endografts, Branched Endografts, Endovascular Aneurysm Repair
Vibrometry: A Novel Non-invasive Application of Ultrasonographic Physics to Estimate Wall Stress in Native Aneurysms
Combining Open and Endovascular Approaches to Complex Aneurysms
Engineering Improvements in Endovascular Devices: Design and Validation
Genetics and Immunology in AAA
The Abdominal Aortic Aneurysm (AAA) is a Specific Antigen-driven T-cell Disease
Genes predisposing to rapid aneurysm growth
Genetic Basis of Thoracic Aortic Aneurysms and Dissections: Potential Relevance toAbdominal Aortic Aneurysms
Structural and Functional Genetic Disorders of the Great Vessels and Outflow Tracts
Genome-wide approach to finding AAA susceptibility genes in humansa
The Candidate Gene Approach to Susceptibility for Abdominal Aortic Aneurysm (AAA): TIMP1, HLA-DR-15, Ferritin Light Chain, and Collagen XI-ALPHA-1
Table of Contents provided by Publisher. All Rights Reserved.

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Abdominal Aortic Aneurysm Genetics, Pathophysiology, and Molecular Biology, Volume 1085

Summary

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Table of Contents

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