Thrombopoiesis and Thrombopoietins

, by Kuter, David J.; Hunt, Pamela; Sheridan, William; Zucker-Franklin, Dorothea

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ISBN: 9780896033795 | 0896033791
Cover: Hardcover
Copyright: 1/1/1997

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David Kuter and a host of leading international researchers summarize in one volume all the knowledge of thrombopoietins (TPO) available today. The distinguished experts review the history of the search to discover TPO, describe the molecular and biological characteristics of this new molecule, and present the results of the preclinical animal experiments that will guide clinical use of this new hormone. Along the way they provide the most recent and comprehensive guide to the biology of megakaryocytes and platelets.

Foreword

(8)

Shirley Ebbe

Preface

xiii

(4)

List of Contributors

xvii

PART I: INTRODUCTION

(92)

1 Megakaryocyte Biology

(38)

Carl W. Jackson

Julie T. Arnold

Tamara I. Pestina

Paula E. Stenberg

2 Platelet Structure and Function

(22)

Dorothea Zucker-Franklin

3 The Evolution of Mammalian Platelets

(16)

Jack Levin

4 Potential Clinical Applications of Thrombopoietic Growth Factors

(16)

Charles A. Schiffer

PART II: THE SEARCH FOR THE PHYSIOLOGIC REGULATOR OF PLATELET PRODUCTION

(86)

5 Historical Perspective and Overview

(14)

Eric M. Mazur

6 The Murine Myeloproliferative Leukemia Virus MPLV, v-mpl Oncogene, and c-mpl

109

(14)

Francoise Wendling

Sylvie Gisselbrecht

7 Mpl Expression and Functional Role in Human Megakaryocytopoiesis

123

(12)

Francoise Wendling

Najet Debili

William Vainchenker

8 The Purification and Cloning of Human Thrombopoietin

135

(8)

Dan Eaton

9 The Purification of Thrombopoietin from Thrombocytopenic Plasma

143

(22)

David J. Kuter

Hiroshi Miyazaki

Takashi Kato

10 The Role of Other Hemopoietic Growth Factors and the Marrow Microenvironment in Megakaryocytopoiesis

165

(16)

Ronald Hoffman

PART III: MOLECULAR BIOLOGY

181

(36)

11 Structure of Thrombopoietin and the Thrombopoietin Gene

181

(8)

Austin L. Gurney

Frederic J. de Sauvage

12 Transcription Factors in Megakaryocyte Differentiation and Gene Expression

189

(14)

Ramesh A. Shivdasani

13 The Biological Significance of Truncated and Full-Length Forms of Mpl Ligands

203

(14)

Donald Foster

Pamela Hunt

PART IV: CELLULAR BIOLOGY

217

(84)

14 In Vitro Effects of Mpl Ligand on Human Hemopoietic Progenitor Cells

217

(20)

Najet Debili

Elisabeth Cramer

Francoise Wendling

William Vainchenker

15 Effect of Cytokines on the Development of Megakaryocytes and Platelets: An Ultrastructural Analysis

237

(20)

Dorothea Zucker-Franklin

16 The Thrombopoietin Receptor, Mpl, and Signal Transduction

257

(14)

Kenneth Kaushansky

Virginia C. Broudy

Jonathan G. Drachman

17 Regulation of Proplatelet and Platelet Formation In Vitro

271

(14)

Esther Choi

In Vitro Effects of Mpl Ligands on Platelet Function

285

(16)

Laurence A. Harker

Ulla M. Marzec

Christopher F. Toombs

PART V: PRECLINICAL BIOLOGY

301

(58)

19 In Vivo Dose-Response Effects of Mpl Ligands on Platelet Production and Function

301

(20)

Laurence A. Harker

Christopher F. Toombs

Richard B. Stead

20 Efficacy of Mpl Ligands and other Thrombopoietic Cytokines in Animal Models

321

(28)

Ann M. Farese

Thomas J. MacVittie

21 Genetic Manipulation of Mpl Ligand and Thrombopoietin In Vivo

349

(10)

Frederic J. de Sauvage

Mark W. Moore

PART VI: CLINICAL BIOLOGY

359

(38)

22 Serum Levels of Thrombopoietin in Health and Disease

359

(18)

Janet Lee Nichol

23 The Regulation of Platelet Production In Vivo

377

(20)

David J. Kuter

Glossary

397

(4)

Index

401

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Thrombopoiesis and Thrombopoietins

Summary

Table of Contents

Supplemental Materials