Emerging Strategies in Neuroprotection

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ISBN: 9780817635442 | 0817635440
Cover: Hardcover
Copyright: 6/1/1992

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NeuroTherapeutics Corp., San Diego, California. Advances in Neuroprotection Series. Overview of research for both clinicians and researchers on rational neuroprotective drug design. Preface defines neuroprotection as protection to the brain cell from injury. 42 Contributors, mostly U.S.

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Foreword
Preface
Contributors
Primary Cultures for Testing Neuroprotective Drugs	p. 3
Modeling Neurodegeneration and Neuroprotection in Hippocampal Slices	p. 24
Stroke Models for Preclinical Trials of Neuroprotective Agents	p. 44
Animal Models of Ischemia	p. 57
Head Trauma Model Systems	p. 76
Excitotoxicity, Cerebral Ischemia, and Neuroprotection by Competitive NMDA Receptor Antagonists	p. 93
Excitatory Amino Acids and Neuroprotection	p. 106
Calcium Channel Blockers and Neuroprotection	p. 129
Self-Defense of the Brain: Adenosinergic Strategies in Neurodegeneration	p. 151
Gangliosides: New Generation of Neuroprotective Agents	p. 187
Lazaroids: Novel Cerebroprotective Antioxidants	p. 224
Membrane-Derived Lipid Second Messengers as Targets for Neuroprotection: Platelet-Activating Factor	p. 238
Protection Against Oxidative Damage to CNS by [alpha]-Phenyl-tert-butyl Nitrone and Other Spin-Trapping Agents: A Novel Series of Nonlipid Free Radical Scavengers	p. 252
Insulin, Hypoglycemia, and Ischemic Neuroprotection	p. 273
Temperature Modulation of Neuronal Injury	p. 289
Clinical Trial Issues in Stroke Therapy	p. 309
Excitotoxicity and Neurodegenerative Disorders	p. 326
Index	p. 345
Table of Contents provided by Blackwell. All Rights Reserved.

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Emerging Strategies in Neuroprotection

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