Aspergillus Fumigatus and Aspergillosis

, by Latge, Jean-Paul; Steinbach, William J.

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ISBN: 9781555814380 | 1555814387
Cover: Hardcover
Copyright: 10/1/2008

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- Focuses on Aspergillus fumigatus, the most serious human pathogen of the Aspergillus genus - Offers an authoritative collection of reviews from both clinical and scientific perspectives - Examines the basic metabolism, genetics, structure, and biochemistry of Aspergillus fumigatus as well as the range of diseases, their diagnosis, their treatment and prophylaxis, and the variability of diseases in specific patient populations - Offers a multidisciplinary approach to better understand the complexity of the situation, and to gain a more complete understanding of this fungus.

Introduction	p. 1
The Species
Morphology and Reproductive Mode of Aspergillus fumigatus	p. 7
Molecular Methods for Species Identification and Strain Typing of Aspergillus fumigatus	p. 15
Aspergillus fumigatus Specificities as Deduced from Comparative Genomics	p. 29
Essential Genes in Aspergillus fumigatus	p. 39
Growth and Sensing, Or Resisting Environmental Stress
Aspects of Primary Carbon and Nitrogen Metabolism	p. 63
Phospholipases of Aspergillus fumigatus	p. 75
Aspergillus fumigatus Secreted Proteases	p. 87
Cations (Zn, Fe)	p. 107
Conidial Germination in Aspergillus fumigatus	p. 131
Growth Polarity	p. 143
Biofilm Formation in Aspergillus fumigatus	p. 149
Signal Transduction	p. 159
Cell Wall of Aspergillus fumigatus: a Dynamic Structure	p. 169
Genetic Regulation of Aspergillus Secondary Metabolites and Their Role in Fungal Pathogenesis	p. 185
Aspergillus fumigatus: Survival and Death under Stress	p. 201
Immune Defense Against Aspergillus
Reactive Oxygen Intermediates, pH, and Calcium	p. 217
Innate Defense against Aspergillus: the Phagocyte	p. 229
Interactions of Aspergillus with the Mucosa	p. 239
Dendritic Cells in Aspergillus Infection and Allergy	p. 247
CD4[superscript +] T-Cell Responses to Aspergillus fumigatus	p. 263
Innate Recognition of Aspergillus fumigatus by the Mammalian Immune System	p. 279
The Spectrum of Disease
Invasive Pulmonary Aspergillosis	p. 293
Aspergillus Sinusitis and Cerebral Aspergillosis	p. 301
Chronic Aspergillosis	p. 319
Allergic Bronchopulmonary Aspergillosis	p. 333
Diagnosis
Histology and Radiology	p. 353
Galactomannan and Anti-Aspergillus Antibody Detection for the Diagnosis of Invasive Aspergillosis	p. 363
Aspergillus PCR	p. 373
Therapy
Polyenes in the Treatment of Aspergillosis	p. 391
Azoles in the Treatment of Aspergillosis	p. 417
Echinocandins in the Treatment of Aspergillosis	p. 435
Antifungal Drug Interactions	p. 445
Antifungal Mechanisms of Action and Resistance	p. 457
Immunotherapy	p. 467
Timing of Antifungal Therapy
Prophylaxis against Invasive Aspergillosis	p. 481
Therapy of Invasive Aspergillosis: Current Consensus and Controversies	p. 491
Specific Patient Populations
Invasive Aspergillosis in Solid Organ Transplant Recipients	p. 503
Invasive Aspergillosis in Malignancy and Stem Cell Transplant Recipients	p. 519
Invasive Aspergillosis in Pediatric Patients	p. 531
Future Directions
A Perspective View of Aspergillus fumigatus Research for the Next Ten Years	p. 549
Index	p. 559
Table of Contents provided by Blackwell. All Rights Reserved.

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Aspergillus Fumigatus and Aspergillosis

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