Transplant Immunology

With all the complex issues of acceptance or rejection of a transplanted organ, immunology is a key subject for all transplantation clinicians. During recent years, there has been an explosion of research and knowledge in this area.

Produced in association with the American Society of Transplantation, and written by experts within the field, Transplant Immunology provides a comprehensive overview of the topic in relation to clinical transplantation.

Starting with the basic functionality of the immune system, it then moves on to cover the very latest developments in immunosuppressive drugs and protocols, as well as a look at all emerging technologies in the field.

Key chapters include:

• Transplant-related complications
• Immune responses to transplants
• Emerging issues in transplantation
• Biomarkers of Allograft rejection and tolerance
• T cells and the principles of immune responses

In full colour throughout, over 100 outstanding diagrams support the text, all figures being fully downloadable via the book's companion website. The result is an essential tool for all those responsible for managing patients awaiting and undergoing organ transplantation, including transplant surgeons and clinicians, immunologists and researchers.

Xian C. Li, MD, PhD, Professor of Immunology/surgery, Weill Cornell Medical College, Cornell University, New York, NY; and Director, Immunobiology and Transplant Science, Houston Methodist Hospital, Texas Medical Center, Houston, TX, USA.

Anthony M. Jevnikar MSc (Immunology), MD, FRCP(C), Professor of Medicine, Surgery, Immunology and Microbiology, Western University, Director Transplantation Nephrology and Director Matthew Mailing Centre for Translational Transplant Studies, London Health Sciences Centre, London ON, Canada.

Contributors, vii

Foreword, xii

Preface, xiv

About the companion website, xv

1 Tissues and organs of the immune system, 1
Isam W. Nasr, Qiang Zeng, and Fadi G. Lakkis

2 Cells of the immune system, 25
Jason R. Lees, Agnes M. Azimzadeh, Yaozhong Ding, Tonya J. Webb, and Jonathan S. Bromberg

3 Soluble mediators in the immune system, 48
Charles A. Su, William M. Baldwin III, and Robert L. Fairchild

4 Costimulatory molecules, 65
Maria�]Luisa Alegre and Anita S. Chong

5 Major histocompatibility complex, 85
Raja Rajalingam, Qiuheng Zhang, J. Michael Cecka, and Elaine F. Reed

6 T cells and the principles of immune responses, 103
Jonathan S. Maltzman, Angus Thomson, and David M. Rothstein

7 Ischemia and reperfusion injury, 128
Yuan Zhai, Yoichiro Uchida, Bibo Ke, Haofeng Ji, and Jerzy W. Kupiec�]Weglinski

8 Immune responses to transplants, 142
Denise J. Lo and Allan D. Kirk

9 Principles of hematopoietic cell transplantation, 164
Sung Choi and Pavan Reddy

10 Therapeutic approaches to organ transplantation, 184
Philip F. Halloran, Chatchai Kreepala, Gunilla Einecke, Alexandre Loupy, and Joana Sellarés

11 Organ�]specific features in clinical transplantation, 217
Roslyn B. Mannon

12 Transplant�]related complications, 237
Leonardo V. Riella and Anil Chandraker

13 Biomarkers of allograft rejection and tolerance, 259
Choli Hartono, Thangamani Muthukumar, and Manikkam Suthanthiran

14 Emerging issues in transplantation, 280
Rupert Oberhuber, Guangxiang Liu, Timm Heinbokel, and Stefan G. Tullius

15 New frontiers and new technologies, 297
Haval Shirwan, Yiming Huang, Kadiyala Ravindra, and Suzanne T. Ildstad

16 Experimental models in discovery and translational studies, 316
Andrew B. Adams, William H. Kitchens, and Kenneth A. Newell

Index, 337

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