Principles of Mass Spectrometry Applied to

An extensive compilation of articles by leading professionals, this reference explains the fundamental principles of mass spectrometry as they relate to the life sciences. Topics covered include spectroscopy, energetics and mechanisms of peptide fragmentation, electron capture dissociation, ion-ion and ion-molecule reactions, reaction dynamics, collisional activation, soft-landing, protein structure and interactions, thermochemistry, and more. The book empowers readers to develop new ways of using these techniques.

JULIA LASKIN, PHD, is a Senior Research Scientist in the Fundamental Sciences Division at the Pacific Northwest National Laboratory in Richland, Washington.

The late CHAVA LIFSHITZ, PHD, was an Archie and Marjorie Sherman Professor of Chemistry in the Department of Physical Chemistry at The Hebrew University in Jerusalem, Israel. She was also on the editorial boards of Mass Spectrometry Reviews and the International Journal of Mass Spectrometry.

Preface.

STRUCTURES AND DYNAMICS OF GAS-PHASE BIOMOLECULES.

Chapter 1. Spectroscopy of neutral Peptides in the Gas Phase-Structure, Reactivity, Microsolvation, Molecular Recognition (M. Gerhards).

Chapter 2. Probing the Electronic Structure of Fe-S Clusters Using Anoin Photoelectron Spectroscopy: Ubiquitous Electron Transfer Centers in Metalloproteins (X. Yang, et al.).

Chapter 3. Ion/Molecule Reactions and H/D Exchange for Structural Characterization of Biomolecules (M. Green & C. Lebrilla).

Chapter 4. Understanding Protein Interactions and their Representation in the Gas Phase of the Mass Spectrometer (F. Sobott & C. Robinson).

Chapter 5. Protein Structure and Folding in the Gas Phase: Ubiquitin and Cytochrome c (K. Breuker).

Chapter 6. Dyunamical Simulations of Photoionization of Small Biological Molecules (D. Shemesh & R. Gerber).

Chapter 7. IVR and Ergodicity of Dissociation of Bio-Molecules (C. Lifshitz).

ACTIVATION, DISSOCIATION AND REACTIVITY.

Chapter 8. Mechanisms of Peptide Fragmentation (V. Wysocki, et al.).

Chapter 9. Peptide Radical Cations (A. Hopkinson & K. Siu).

Chapter 10. Photodissociation of Biomolecule Ions: Progress, Possibilities, and the Perspectives Coming From Small-Ion Models (R. Dunbar).

Chapter 11. Chemical Dynamics Simulations of EnergyTransfer and Unimolecular Decomposition in Collision-Induced Dissociation (CID) and Surface-Induced Dissociation (SID) (A. Rahaman, et al.).

Chapter 12. Ion Soft Landing: Instrumentation, Phenomena and Applications (B. Gologan, et al.).

Chapter 13. Electron Capture Dissociation and Other Ion-electron Fragmentation Reactions (R. Zubarev).

Chapter 14. Biomolecule Ion/Ion Reactions (S. McLuckey).

THERMOCHEMISTRY AND ENERGETICS.

Chapter 15. Thermochemistry Studies of Biomolecules (C. Wesdemiotis).

Chapter 16. Energy and Entropy Effects in the Gas Phase Dissociation of Peptides and Proteins (J. Laskin).

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Principles of Mass Spectrometry Applied to Biomolecules

Summary

Author Biography

Table of Contents

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