A Practical Manual of Diabetes in Pregnancy

A PRACTICAL MANUAL OF DIABETES IN PREGNANCY

The second edition of A Practical Manual of Diabetes in Pregnancy offers a wealth of new evidence, new material, new technologies, and the most current approaches to care. With contributions from a team of international experts, the manual is highly accessible and comprehensive in scope. It covers topics ranging from preconception to postnatal care, details the risks associated with diabetic pregnancy, and the long-term implications for the mother and baby. The text also explores recent controversies and examines thorny political pressures.

The manual’s treatment recommendations are based on the latest research to ensure pregnant women with diabetes receive the best possible care. The text takes a multi-disciplinary approach that reflects best practice in the treatment of diabetes in pregnancy. The revised second edition includes:

• New chapters on the very latest topics of interest
• Contributions from an international team of noted experts
• Practical, state-of-the-art text that has been fully revised with the latest in clinical guidance
• Easy-to-read, accessible format in two-color text design
• Illustrative case histories, practice points, and summary boxes, future directions, as well as pitfalls and what to avoid boxes
• Multiple choice questions with answers in each chapter

Comprehensive and practical, the text is ideal for use in clinical settings for reference by all members of the multi-disciplinary team who care for pregnant women with diabetes. The manual is also designed for learning and review purposes by trainees in endocrinology, diabetes, and obstetrics.

David R. McCance, Endocrinologist, Royal Victoria Hospital, Belfast, UK

Michael Maresh, Obstetrician, St Mary's Hospital, Manchester, UK

David A. Sacks, Obstetrician, Kaiser Permanente Southern California, Pasadena, USA

Contributors ix

Foreword xiii

Preface xv

Section I Introduction 1

1 Epidemiology of Diabetes in Pregnancy 3
David Simmons

2 Pathophysiology of Diabetes in Pregnancy 17
Francine Hughes Einstein

3 The Placenta in a Diabetic Pregnancy 31
Ursula Hiden and Gernot Desoye

Section II Gestational Diabetes 47

4 Screening for Gestational Diabetes 49
David A. Sacks

5 Diagnostic Criteria for Hyperglycemia in Pregnancy 61
Robert S. Lindsay

6 Lifestyle Treatment 73
Christina Anne Vinter and Dorte Moller Jensen

7 Obesity and Diabetes in Pregnancy 87
H. David McIntyre, Marloes Dekker Nitert , Helen L. Barrett and Leonie K. Callaway

8 Metabolic Abnormalities in Gestational Diabetes 105
Ravi Retnakaran

9 Maternal Risk After the Gestational Diabetes Mellitus Pregnancy 115
Lisa Chasan�]Taber and Catherine Kim

Section III Diabetes Preceding Pregnancy 127

10 Pre�]Pregnancy Care in Type 1 and Type 2 Diabetes 129
Rosemary C. Temple and Katharine P. Stanley

11 Malformations 141
Montserrat Balsells, Apolonia Garcia�]Patterson, Juan Maria Adelantado and Rosa Corcoy

12 Provision of Pregnancy Care 153
Jenny Myers, Susan Quinn, Gretta Kearney, Susan Curtis, Prasanna Rao�]Balakrishna and Michael Maresh

13 Problems Encountered More Frequently in Women with Type 1 Diabetes 167
Una M. Graham, Michael Maresh and David R. McCance

14 Problems Encountered More Frequently in Women with Type 2 Diabetes 179
Lorie M. Harper

15 Advances in Oral Anti�]Diabetes Drugs in Pregnancy 189
Geetha Mukerji and Denice S. Feig

16 Advances in Insulin Therapy 203
Gioia N. Canciani, Zoe A. Stewart and Helen R. Murphy

17 Putting Pregnant Women with Diabetes on the Pump 215
Peter Hammond

18 Pregnancy, Perinatal, and Fertility Outcomes Following Bariatric Surgery 227
Aubrey R. Raimondi and Eyal Sheiner

19 Fetal Surveillance 243
Dipanwita Kapoor and Nia Jones

20 Complications in Pregnancy: Hypertension and Diabetic Nephropathy in Diabetes in Pregnancy 257
Elisabeth R. Mathiesen, Lene Ringholm and Peter Damm

21 Retinopathy in Diabetic Pregnancy 269
Jesia Hasan and Emily Y. Chew

Section IV Delivery and Postnatal Care 285

22 Delivery and Postdelivery Care: Obstetric Management of Labor, Delivery, and the Postnatal Period for Women with Type 1, Type 2, or Gestational Diabetes Mellitus 287
Jacques Lepercq

23 Diabetic Management in Labor, Delivery, and Postdelivery 297
Una M. Graham and David R. McCance

24 Delivery and Postdelivery Care: Care of the Neonate 309
Jane M. Hawdon

25 Postpartum Contraception for Women with Diabetes 325
Anita L. Nelson

26 Breastfeeding and Diabetes 341
Elizabeth Stenhouse

Section V Implications for the Future 353

27 Implications for the Mother with Diabetes 355
Ewa Wender�]Ozegowska and David A. Sacks

28 Diabetes in Pregnancy: Implications for the Offspring 367
Anne P. Starling and Dana Dabalea

29 From the Bench to the Bedside: Potential Future Therapies for Gestational Diabetes – The Enhancement of β�]Cell Mass and Function During Pregnancy 377
David J. Hill

Index 393

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