Juvenile Huntington's Disease and other trinucleotide repeat disorders
, by Quarrell, Oliver W.J.; Brewer, Helen M.; Squitieri, Ferdinando; Barker, Roger A.; Nance, Martha A.; Landwehrmeyer, G. BernhardNote: Supplemental materials are not guaranteed with Rental or Used book purchases.
- ISBN: 9780199236121 | 0199236127
- Cover: Hardcover
- Copyright: 3/15/2009
Huntington's disease (HD) is an inherited progressive neurodegenerative disorder. Although onset of Huntington's Disease usually occurs in adulthood, the age of onset of the condition is extremely variable with approximately 5-10% of cases having an onset of less than 20 years, or JuvenileHuntington's Disease (JHD). While JHD shares many of the clinical features of adult HD (e.g., chorea and personality disorders), patients with JHD often experience additional problems including seizures, dystonia and Parkinsonism. Diagnosis in patients with JHD is often delayed because of thefailure of clinicians to recognise the characteristic features of the condition. While several textbooks have been published on HD, no books have been published to date focussing solely on the juvenile onset form of the disease. This book summarises, for the first time, the clinical and scientificknowledge available on JHD. It also collects together accounts from families affected by the condition, putting the clinical and scientific chapters into context.Edited by members of the working party European Huntington's Disease Network (EHDN), this book forms the first comprehensive text on JHD and is of interest to neurologists, geneticists, academic/research scientists and other healthcare professionals.