Pharmacodynamics and Drug Development

In recent years it has become clear that early information about pharmacodynamics leads to more efficient trial designs and improved clinical guidelines for the use of all drugs. Spanning many of the major drug classes, this book offers the essential facts and concepts and includes an authoritative section on general methodology and regulatory issues. The molecular biology and pharmacology of major receptor types are considered, as is the detailed pharmacodynamics of a wide range of therapeutic drug classes. The book will be of interest to researchers, clinical pharmacologists, physicians and regulators working in academia as well as the pharmaceutical industry worldwide.

Neal R. Cutler is the editor of Pharmacodynamics and Drug Development: Perspectives in Clinical Pharmacology, published by Wiley. John J. Sramek is the editor of Pharmacodynamics and Drug Development: Perspectives in Clinical Pharmacology, published by Wiley.

Partial table of contents:

OVERVIEW OF PHARMACODYNAMICS.

Basic Pharmacodynamic Concepts and Models (R. Wills).

Factors Influencing Variability in Kinetics and Dynamics (P. Narang & R. Li).

General Perspectives on the Role of Metabolite in Pharmacokinetics and Pharmacodynamics (R. Seifert).

Regulatory Perspective: The Role of Pharmacokinetics and Pharmacodynamics (L. Lesko & R. Williams).

APPLICATION OF PHARMACODYNAMICS IN SELECTED THERAPEUTIC DOMAINS.

Theoretical Models for Developing Anxiolytics (P. Nickell & T. Uhde).

Pharmacodynamics of Antipsychotic Drugs in Schizophrenia (J. Sramek & G. Simpson).

Antihypertensive Drugs (L. Prisant & A. Carr).

Pharmacodynamics of Antineoplastic Agents (G. Rosner & M. Ratain).

Virology and Antiviral Drug Development (M. Amantea, et al.).

FRONTIERS IN PHARMACODYNAMICS: INSIGHT FROM MOLECULAR APPROACHES.

Muscarinic Receptors: Pharmacological Subtypes, Structure, Function and Regulation (L. Mei, et al.).

Serotonin Receptor Subtypes (D. Pritchett).

Index.

What is included with this book?

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Pharmacodynamics and Drug Development Perspectives in Clinical Pharmacology

Summary

Author Biography

Table of Contents

Supplemental Materials