The Antimicrobial Drugs

The is the third edition of a text that surveys the drugs used to treat bacterial, fungal, prarsitic, and viral infections. This book contains comprehensive presentations of the mechanisms for both the antimicrobial actions and for the adverse clinical effects of these drugs. Completediscussions of the pharmacology are highlighted by numerous charts and tables summarizing each drug's pharmacokinetic properties and microbial susceptibility. With 3500 reference citations, The Anitmicrobial Drugs provides a complete entry into the literature, making it an invaluable resource forinfectious disease specialists, clinical pharmacists, clinical microbiologists, medical students, pharmacy students, and graduate students in pharmacology and microbiology.

PART 1 PRINCIPLES OF ANTIMICROBIAL THERAPY

Determinants of Bacterial Response to Antimicrobial Agents

3

(34)

Drug Resistance

37

(14)

PART 2 DRUGS EMPLOYED IN THE TREATMENT OF BACTERIAL INFECTIONS

The Inhibitors of Cell Wall Synthesis, I

51

(30)

Mechanism of Action of the Penicillins, Cephalosporins, Vancomycin, and Other Inhibitors of Cell Wall Synthesis

The Inhibitors of Cell Wall Synthesis, II

81

(46)

Pharmacology and Adverse Effects of the Penicillins, Cephalosporins, Carbapenems, Monobactams, Vancomycin, and Bacitracin

Bactericidal Inhibitors of Protein Synthesis

127

(32)

The Aminoglycosides

Bacteriostatic Inhibitors of Protein Synthesis

159

(52)

Chloramphenicol, Macrolides, Clindamycin, Spectinomycin, Tetracyclines, and Streptogramins

The Antimetabolites

211

(23)

The Sulfonamides and Trimethoprim (Trimethoprim-Sulfamethoxazole)

Antibiotics that Affect Membrane Permeability

234

(8)

Polymyxin B, Colistin, and Gramicidin A

The Urinary Tract Antiseptics

242

(15)

Nalidixic Acid and Cinoxacin; Nitrofurantoin; Methenamine; Fosfomycin

The Fluoroquinolones

257

(23)

Drugs that Act on Mycobacteria

280

(47)

Isoniazid, Rifampin, Ethambutol, Streptomycin, and Pyrazinamide; The Second-Line Antituberculosis Drugs; Drugs Effective Against Leprosy; Drugs Effective Against the Mycobacterium avium Complex

PART 3 DRUGS EMPLOYED IN THE TREATMENT OF FUNGAL INFECTIONS

Antifungal Drugs

327

(48)

The Polyene Antibiotics, Flucytosine, Azoles, Iodide, Griseofulvin, and Topical Agents

PART 4 DRUGS EMPLOYED IN THE TREATMENT OF PARASITIC DISEASE

Chemotherapy of Malaria

375

(44)

Chemotherapy of Protozoal Diseases

419

(39)

Chemotherapy of Helminthic Diseases

458

(33)

PART 5 DRUGS EMPLOYED IN THE TREATMENT OF VIRAL INFECTIONS

Chemotherapy of Viral Infections, I

491

(59)

Drugs Used to Treat Influenza Virus Infections, Herpesvirus Infections, and Drugs with Broad-Spectrum Antiviral Activity

Chemotherapy of Infections, II

550

(37)

Antiretroviral Agents

Index

587

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The Antimicrobial Drugs

Summary

Table of Contents

Supplemental Materials